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[{"key": "dc.contributor.advisor", "value": "Astikainen, Piia", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Pirttim\u00e4ki, Tiina", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Kyl\u00e4heiko, Iiris", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2017-08-25T12:08:36Z", "language": "", "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2017-08-25T12:08:36Z", "language": "", "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2017", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.other", "value": "oai:jykdok.linneanet.fi:1719664", "language": null, "element": "identifier", "qualifier": "other", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/55183", "language": "", "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Ihmisaivot ovat taipuvaiset havaitsemaan muutoksia kuuloymp\u00e4rist\u00f6ss\u00e4\u00e4n. Elektrofysiologisissa mittauksissa t\u00e4m\u00e4n automaattisen muutoksen havaitsemisen merkkin\u00e4 voidaan k\u00e4ytt\u00e4\u00e4 poikkeavuusnegatiivisuutta (MMN), joka on negatiivinen komponentti her\u00e4tysvasteessa. Viel\u00e4 ei kuitenkaan tiedet\u00e4, onko hiirill\u00e4 toiminnallisesti samanlaista vastetta kuin ihmisill\u00e4. T\u00e4h\u00e4n kysymykseen vastataksemme nauhoitimme kentt\u00e4potentiaaleja uretaanianestesiassa olevien hiirten kuuloaivokuorelta. Ensimm\u00e4isess\u00e4 kokeessa esitimme hiirille harvinaisia muutoksia (12.5 %) \u00e4\u00e4nen taajuudessa kahdella eri \u00e4rsykev\u00e4lill\u00e4 (ISI). Toisessa kokeessa hiirille esitettiin lyhennyksi\u00e4 (45 % ja 35 %) /a/-puhe\u00e4\u00e4niss\u00e4. Taajuuskokeessa poikkeavuusvaste (MMR) syntyi sek\u00e4 laskeviin ett\u00e4 nouseviin taajuusmuutoksiin. \u00c4rsykev\u00e4lin pident\u00e4minen johti poikkeavuusvasteen vaimentumiseen, joka johtui heikenneest\u00e4 muistij\u00e4ljen muodostumisesta. My\u00f6s toisessa kokeessa esitetyt puhe\u00e4\u00e4nen pituuden vaihtelut saivat aikaan poikkeavuusvasteen hiirill\u00e4. K\u00e4ytimme my\u00f6s ensimm\u00e4ist\u00e4 kertaa hiirill\u00e4 kontrollikoetta, jonka tarkoituksena oli selvitt\u00e4\u00e4 poikkeavuusvasteen hermostollista perustaa. Tulokset tukevat teoriaa, jonka mukaan poikkeavuusvaste perustuisi hiirill\u00e4 muistipohjaiseen vertailuprosessiin, vastaavasti kuten poikkeavuusnegatiivisuus ihmisill\u00e4, ainakin taajuusmuutoksien kohdalla. Yhdess\u00e4 kokeiden tulokset osoittavat, ett\u00e4 poikkeavuusvastetta voidaan jatkossa k\u00e4ytt\u00e4\u00e4 hiirimalleissa v\u00e4lineen\u00e4 tutkia sensoris-kognitiivisia toimintoja. T\u00e4m\u00e4 tulos on hy\u00f6dyllinen, sill\u00e4 tarjolla on suuri m\u00e4\u00e4r\u00e4 geneettisi\u00e4 hiirimalleja, ja lis\u00e4\u00e4 tutkimusta tarvitaan kognitiivisten toimintojen, kuten puheen, sek\u00e4 neuropsykiatristen sairauksien, kuten dysleksian, neurobiologiaan liittyen.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Human brain is prone to encode changes in the auditory environment. In the electrophysiological recordings, this automatic ability can be indexed by the mismatch negativity (MMN), a negative component of an event-related potential. However, it remains unsolved, whether a functionally similar response is also elicited in mice. To address this question, we recorded local field potentials from the auditory cortex for the first time in urethane-anesthetized mice. In the first experiment, we presented rare changes (12.5 %) in sound frequencies with two different inter-stimulus intervals (ISIs). In the second experiment, decremental changes (45 % and 35 %) in durations of human speech /a/-sounds were presented. In the frequency change experiment, mismatch response (MMR) was elicited to both ascending and descending changes in frequency. Lengthening of the ISI resulted in attenuation of the MMR, indicating weakened memory trace formation. In the duration change experiment, MMR was elicited to both changes. For the first time in mice, we also applied an equiprobable control condition in both experiments to investigate the neural basis of the MMR. The results support the hypothesis of MMR being created in a memory-based comparison process in mice, similarly to human MMN, at least for frequency changes. Together, these results suggest that MMR can be applied as a research tool to study sensory-cognitive functions in a mouse model. This is especially beneficial because of the large genetic toolbox, which is available for mice and the existing need for more research of the neurobiology of cognitive functions such as speech, as well as of neuropsychiatric disorders, such as dyslexia.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Iiris Kyl\u00e4heiko (iisikyla) on 2017-08-25 12:08:35.264317. Form: Pro gradu -lomake (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/pro-gradu-lomake). JyX data: [jyx_publishing-allowed (fi) =False]", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija.group@korppi.jyu.fi) on 2017-08-25T12:08:36Z\r\nNo. of bitstreams: 2\r\nURN:NBN:fi:jyu-201708253569.pdf: 6841705 bytes, checksum: 4497fca25b0a881424a98b5dbd203eb3 (MD5)\r\nlicense.html: 1161 bytes, checksum: 595a5c333ec31b092c77817e46a7dfbb (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2017-08-25T12:08:36Z (GMT). No. of bitstreams: 2\r\nURN:NBN:fi:jyu-201708253569.pdf: 6841705 bytes, checksum: 4497fca25b0a881424a98b5dbd203eb3 (MD5)\r\nlicense.html: 1161 bytes, checksum: 595a5c333ec31b092c77817e46a7dfbb (MD5)\r\n Previous issue date: 2017", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "1 verkkoaineisto (44 sivua)", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "mismatch negativity (MMN)", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "mismatch response (MMR)", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "change detection", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "auditory cortex", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "local field potential (LFP)", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "mouse", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "urethane-anesthesia", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "memory-trace hypothesis", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "sound duration", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "sound frequency", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "inter-stimulus interval (ISI) manipulation", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Electrophysiological evidence for change detection in sound frequency and duration in mice", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201708253569", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, 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Aineisto on luettavissa Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6asemalta. Ks. https://kirjasto.jyu.fi/fi/tyoskentelytilat/laitteet-ja-tilat.", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "This material has a restricted access due to copyright reasons. It can be read at the workstation at Jyv\u00e4skyl\u00e4 University Library reserved for the use of archival materials: https://kirjasto.jyu.fi/en/workspaces/facilities.", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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