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[{"key": "dc.contributor.advisor", "value": "Pekkala, Satu", "language": null, "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Yl\u00e4nne, Jari", "language": null, "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "V\u00e4lim\u00e4ki, Sakari", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2017-05-09T09:18:46Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2017-05-09T09:18:46Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2017", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.other", "value": "oai:jykdok.linneanet.fi:1700597", "language": null, "element": "identifier", "qualifier": "other", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/53840", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Alkoholista riippumaton rasvamaksa (NAFLD) on maailman yleisin maksasairaus ja saattaa johtaa kirroosin tai maksasy\u00f6v\u00e4n kehittymiseen. Viimeaikaisissa tutkimuksissa suolistosta per\u00e4isin olevin bakteerimolekyylien, kuten flagelliinin (FLG) ja lipopolysakkaridien (LPS), rooli rasvamaksan kehittymisess\u00e4 on tunnistettu. N\u00e4m\u00e4 molekyylit saattavat vaikuttaa maksaan v\u00e4lillisesti rasvakudoksen kautta toll-like reseptorien (TLR) signaalireittej\u00e4 aktivoiden. T\u00e4ss\u00e4 tutkimuksessa selvitettiin FLG:n ja LPS:n rasvasoluv\u00e4litteisi\u00e4 vaikutuksia HepG2-hepatoomasoluihin. Hypoteesina oli, ett\u00e4 FLG ja LPS lis\u00e4isiv\u00e4t HepG2 soluissa rasvan ker\u00e4\u00e4ntymist\u00e4, insuliiniresistenssi\u00e4 ja tulehdusta, joita mitattiin kvantitatiivisella PCR:ll\u00e4 sek\u00e4 western blotilla. Tulokset osoittavat, ett\u00e4 FLG saattaa vaikuttaa rasvamaksan kehitykseen erityisesti adiposyyttien kautta.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world, and may lead to development of cirrhosis or hepatocellular carcinoma. Lately the role of molecules from gut-derived bacteria, like flagellin (FLG) and lipopolysaccharides (LPS) in development of NAFLD has been recognized. These molecules could affect the liver indirectly through activation of adipose tissue toll-like receptor (TLR) pathways. In this study the potential adipocyte mediated effects of FLG and LPS on HepG2 hepatoma cells were explored. The hypothesis was that FLG and LPS would increase HepG2 fat accumulation, insulin resistance and inflammation measured with quantitative realtime PCR (qPCR) and western blot. According to the results especially adipocyte mediated FLG could have a role in fatty liver development.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Sakari V\u00e4lim\u00e4ki (samivali) on 2017-05-09 09:18:45.576336. Form: Pro gradu -lomake (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/pro-gradu-lomake). JyX data: [jyx_publishing-allowed (fi) =True]", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija.group@korppi.jyu.fi) on 2017-05-09T09:18:45Z\nNo. of bitstreams: 2\nURN:NBN:fi:jyu-201705092246.pdf: 1153784 bytes, checksum: c0cfa26722a2f7dcfc8113dae3487f4c (MD5)\nlicense.html: 4912 bytes, checksum: fc0e936236c9177a87bb5eea9d4606a1 (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2017-05-09T09:18:46Z (GMT). No. of bitstreams: 2\nURN:NBN:fi:jyu-201705092246.pdf: 1153784 bytes, checksum: c0cfa26722a2f7dcfc8113dae3487f4c (MD5)\nlicense.html: 4912 bytes, checksum: fc0e936236c9177a87bb5eea9d4606a1 (MD5)\n Previous issue date: 2017", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "1 verkkoaineisto (37 sivua)", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "alkoholista riippumaton rasvamaksa", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "toll-like reseptori", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "An in vitro model to study the adipose tissue toll-like receptor -mediated effects of gut microbiota on non-alcoholic fatty liver disease development", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201705092246", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Bio- ja ymp\u00e4rist\u00f6tieteiden laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Biological and Environmental Science", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Solu- ja molekyylibiologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Cell and molecular biology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.date.updated", "value": "2017-05-09T09:18:46Z", "language": null, "element": "date", "qualifier": "updated", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": null, "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": "fi", "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4013", "language": null, "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "rasvamaksa", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "reseptorit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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