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[{"key": "dc.contributor.author", "value": "Piitulainen, Harri", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2017-01-25T09:51:53Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2017-01-25T09:51:53Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2005", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/52852", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4m\u00e4n tutkimuksen tarkoitus oli selvitt\u00e4\u00e4 uupumukseen asti suoritetun venymis-\nlyhenemissykli tyyppisen kuormituksen vaikutuksia dystrofiinin, \u03b1-syntrofiinin ja Na+-\nkanavien vasta-ainev\u00e4rj\u00e4ytymiseen ja geenien ilmentymiseen heti ja kaksi p\u00e4iv\u00e4\u00e4 \nkuormituksen j\u00e4lkeen. Lis\u00e4ksi tarkoituksena oli selvitt\u00e4\u00e4 aiheuttaako kyseinen kuormitus\nmuutoksia hermolihasj\u00e4rjestelm\u00e4n suorituskyvyss\u00e4 tai elektromyografiassa. \n\n \n\nLihasv\u00e4symyksen aiheuttamaa voimantuottokyvyn heikkenemist\u00e4 on selitetty \u00e4rsytys-\nsupistus koplauksen (ECC) h\u00e4iriintymisell\u00e4, jossa sarkoplasmisen retikkelin (SR) Ca2+\nkinetiika h\u00e4iriintyy. Mahdollinen syy t\u00e4lle h\u00e4iri\u00f6lle voi olla Na+-kanavien toiminnan\nh\u00e4iriintyminen, jolloin sarkolemman aktiopotentiaalin (AP) johtumisominaisuudet\nheikkenev\u00e4t. Solutukirangan proteiinilla, \u03b1- syntrofiinilla on todenn\u00e4k\u00f6isesti yhdess\u00e4\ndystrofiinin ja dystrobreviinin kanssa Na+-kanavia stabiloiva rooli, joten n\u00e4iden \nsolutukirangan proteiinien vaurio/h\u00e4iri\u00f6 saattaisi aiheuttaa Na+-kanavien toiminnallisen\nh\u00e4iri\u00f6n. Aikaisemmin on havaittu dystrofiinin olevan herkk\u00e4 eksentriselle kuormitukselle.\n\n \n\nVaikka kuormitus aiheutti lihasvauriolle tyypilliset muutokset mm. seerumin \nkreatiinikinaasissa, voimantuottokyvyss\u00e4 ja lihasarkuudessa, niin kudostasolla ei havaittu\nselke\u00e4\u00e4 lihassolujen vaurioitumista. My\u00f6sk\u00e4\u00e4n dystrofiinin, \u03b1-syntrofiinin tai \nnatriumionikanavien geneettisess\u00e4 s\u00e4\u00e4telyss\u00e4 ja dystrofiinin ja \u03b1-syntrofiinin vasta-\nainev\u00e4rj\u00e4ytymisess\u00e4 ei havaittu muutoksia. N\u00e4iden proteiinien osalta geneettinen s\u00e4\u00e4tely\nsaattaa tapahtua my\u00f6hemm\u00e4ss\u00e4 vaiheessa kuin kaksi p\u00e4iv\u00e4\u00e4 kuormituksen j\u00e4lkeen.\nLis\u00e4ksi \u03b1-syntrofiinin ja natriumionikanavien suhteellisilla muutoksilla oli vahva \nriippuvuus, joka voisi kertoa n\u00e4iden proteiinien toiminnallisesta riippuvuudesta. Jatkossa\ntulisi selvitt\u00e4\u00e4 laajemmin dystrofiinikompleksin, siihen liittyvien proteiinien ja \nsarkolemman ionikanavien s\u00e4\u00e4tely ja rooli lihasvaurion yhteydess\u00e4 ihmisill\u00e4. Lis\u00e4ksi\nsarkolemman mahdolliset toiminnalliset muutokset vaativat lis\u00e4tutkimuksia.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Miia Hakanen (mihakane) on 2017-01-25 09:51:53.143990. Form: Admin-lomake opinn\u00e4ytteiden julkaisuun (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/admin-lomake-opinnaytteet). JyX data: [jyx_publishing-allowed (fi) =False]", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija.group@korppi.jyu.fi) on 2017-01-25T09:51:53Z\nNo. of bitstreams: 2\nURN:NBN:fi:jyu-201701251262.pdf: 1559239 bytes, checksum: 054908d9a28845525fbb52185070f7d5 (MD5)\nlicense.html: 107 bytes, checksum: a7d86e598caa500b1b433bbb9dc8ef1c (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2017-01-25T09:51:53Z (GMT). No. of bitstreams: 2\nURN:NBN:fi:jyu-201701251262.pdf: 1559239 bytes, checksum: 054908d9a28845525fbb52185070f7d5 (MD5)\nlicense.html: 107 bytes, checksum: a7d86e598caa500b1b433bbb9dc8ef1c (MD5)\n Previous issue date: 2005", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "53", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "dystrofiini", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "syntrofiini", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "natriumionikanava", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "dystrofiinikompleksi", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "sarkolemma", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "lihasvaurio", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "\u00e4rsytys-supistus koplaus", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "venymis-lyhenemissykli", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "PCR", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "immunohistokemia", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Dynaamisen v\u00e4sytyskuormituksen molekulaariset vasteet dystrofiininssa, \u03b1-syntrofiinissa ja natriumionikanavissa", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "bachelor thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201701251262", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Bachelor's thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Kandidaatintutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Liikuntatieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Liikuntabiologian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Liikuntafysiologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.date.updated", "value": "2017-01-25T09:51:54Z", "language": null, "element": "date", "qualifier": "updated", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": null, "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_7a1f", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "restrictedAccess", "language": "fi", "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "bachelorThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "This material has a restricted access due to copyright reasons. It can be read at the workstation at Jyv\u00e4skyl\u00e4 University Library reserved for the use of archival materials: https://kirjasto.jyu.fi/en/workspaces/facilities.", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "Aineistoon p\u00e4\u00e4sy\u00e4 on rajoitettu tekij\u00e4noikeussyist\u00e4. Aineisto on luettavissa Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6asemalta. Ks. https://kirjasto.jyu.fi/fi/tyoskentelytilat/laitteet-ja-tilat.", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}]
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