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[{"key": "dc.contributor.author", "value": "Piitulainen, Harri", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2017-01-25T09:49:49Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2017-01-25T09:49:49Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2004", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/52851", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4m\u00e4n tutkielman tarkoitus oli selvitt\u00e4\u00e4 kirjallisuuteen perustuen mit\u00e4 menetelmi\u00e4 on \nk\u00e4ytetty lihasvaurion tutkimuksessa ja mik\u00e4 on lihasvaurion syntymekanismi. Lis\u00e4ksi \ntarkoituksena oli selvitt\u00e4\u00e4 lis\u00e4tutkimuksien tarvetta aiheesta, miten ja mill\u00e4 menetelmill\u00e4 \nlihasvauriota tulisi tulevaisuudessa tutkia. \n\n \n\nLihasvaurio syntyy raskaan fyysisen kuormituksen seurauksena. Lihasvaurio n\u00e4kyy \nmuutoksina solutasolla ja lihaksen toiminnan tasolla. Lihasvauriotutkimuksessa on \nk\u00e4ytetty laaja-alaisesti eri menetelmi\u00e4. Lihasvauriota on arvioitu lihaksen toimintakyky\u00e4 \nkuvaavien-, vauriota suoraan kuvaavien- ja vauriosta ep\u00e4suorasti kertovien muuttujien \navulla. Lihasvaurion syntymekanismi on vaiheittain etenev\u00e4 lihaskudoksen rakenteiden \nde- ja regeneratiivisia prosesseja sis\u00e4lt\u00e4v\u00e4 tapahtuma. Monia mekanismeja on ehdotettu \nselitt\u00e4m\u00e4\u00e4n lihasvaurion synty- ja palautumisprosessia kuten lihasmekaaniset tekij\u00e4t, \nlihaksen rakenteellisten proteiinien vaurioituminen, muutokset lihassolun kalsium \nhomeostaasissa, muutokset \u00e4rsytys-supistus koplauksessa, akuutti tulehdusreaktio ja \nmyofibrillien adaptiivinen uudismuodostus. \n\n \n\nLihasvaurion syntymekanismi on monilta osin viel\u00e4 ep\u00e4selv\u00e4, mutta n\u00e4ytt\u00e4\u00e4 silt\u00e4, ett\u00e4 \nniin mekaaniset ett\u00e4 kemialliset tapahtumat johtavat lihasvaurion syntyyn. My\u00f6hemmiss\u00e4 \nlihasvaurion vaiheissa tapahtuu lihassolun proteiinirakenteiden hajoamista ja synteesi\u00e4 \ngeenien, entsyymien ja tulehdussolujen toiminnan vaikutuksesta. Lihasvaurioon liittyvien \nmolekyylitason mekanismien selvitt\u00e4miseksi, tulevaisuuden tutkimuksien tulisi \nhy\u00f6dynt\u00e4\u00e4 laaja-alaisesti k\u00e4yt\u00f6ss\u00e4 olevia tutkimusmenetelmi\u00e4. Etenkin geenien \nilmentymisen tutkiminen lihasvaurion yhteydess\u00e4 tarjoaa mahdollisuuden lihasvaurion \nluonteen laaja-alaisempaan ymm\u00e4rrykseen.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Miia Hakanen (mihakane) on 2017-01-25 09:49:48.591290. Form: Admin-lomake opinn\u00e4ytteiden julkaisuun (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/admin-lomake-opinnaytteet). JyX data: [jyx_publishing-allowed (fi) =False]", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija.group@korppi.jyu.fi) on 2017-01-25T09:49:49Z\nNo. of bitstreams: 2\nURN:NBN:fi:jyu-201701251261.pdf: 1709766 bytes, checksum: 7673a101636d71cea6826992dba99fda (MD5)\nlicense.html: 107 bytes, checksum: a7d86e598caa500b1b433bbb9dc8ef1c (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2017-01-25T09:49:49Z (GMT). No. of bitstreams: 2\nURN:NBN:fi:jyu-201701251261.pdf: 1709766 bytes, checksum: 7673a101636d71cea6826992dba99fda (MD5)\nlicense.html: 107 bytes, checksum: a7d86e598caa500b1b433bbb9dc8ef1c (MD5)\n Previous issue date: 2004", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "72", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "ihasvaurio", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "lihasarkuus", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "luurankolihas", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "solutukiranka", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "sarkomeeri", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "myofibrilli", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "eksentrinen lihasty\u00f6", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "\u00e4rsytys-supistus koplaus", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "kalsium-homeostaasi", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Lihasvaurion mahdollinen syntymekanismi ja sen tutkimuksessa k\u00e4ytetyt menetelm\u00e4t", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "bachelor thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201701251261", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Bachelor's thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Kandidaatintutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Liikuntatieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Liikuntabiologian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Biomekaniikka", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.date.updated", "value": "2017-01-25T09:49:50Z", "language": null, "element": "date", "qualifier": "updated", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": null, "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_7a1f", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "restrictedAccess", "language": "fi", "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "bachelorThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "This material has a restricted access due to copyright reasons. It can be read at the workstation at Jyv\u00e4skyl\u00e4 University Library reserved for the use of archival materials: https://kirjasto.jyu.fi/en/workspaces/facilities.", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "Aineistoon p\u00e4\u00e4sy\u00e4 on rajoitettu tekij\u00e4noikeussyist\u00e4. Aineisto on luettavissa Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6asemalta. Ks. https://kirjasto.jyu.fi/fi/tyoskentelytilat/laitteet-ja-tilat.", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}]
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