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[{"key": "dc.contributor.advisor", "value": "Lahtinen, Tanja", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Marjom\u00e4ki, Varpu", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Saarnio, Ville", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2017-01-20T11:00:28Z", "language": "", "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2017-01-20T11:00:28Z", "language": "", "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2017", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.other", "value": "oai:jykdok.linneanet.fi:1659307", "language": null, "element": "identifier", "qualifier": "other", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/52777", "language": "", "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Enteroviruksilla on suuri merkitys nykymaailmassa. Ne ovat vastuussa sek\u00e4 suuresta osasta harmittomia tartuntoja ett\u00e4 hengenvaarallisista taudeista. J\u00e4lkimm\u00e4isist\u00e4 parhaiten tunnettu esimerkki lienee polioviruksen aiheuttama polio. Vaikka rokotteet tarjoavat suojaa poliolta ja joiltain muilta taudeilta, niist\u00e4 ei ole lopulliseksi ratkaisuksi, sill\u00e4 ne eiv\u00e4t auta jo tartunnan saaneita ihmisi\u00e4. T\u00e4t\u00e4 varten tarvitaan antiviraaleja, yhdisteit\u00e4, jotka est\u00e4v\u00e4t virusten lis\u00e4\u00e4ntymist\u00e4. Tutkimus yhdisteiden kehitt\u00e4miseksi enteroviruksia vastaan on jatkunut jo vuosikymmeni\u00e4, mutta ainuttakaan l\u00e4\u00e4kett\u00e4 ei ole viel\u00e4 saatu yleiseen hoitok\u00e4ytt\u00f6\u00f6n. Monia potentiaalisia yhdisteit\u00e4 on t\u00e4n\u00e4 aikana kehitetty ja joitakin testattu kliinisiss\u00e4 kokeissa, mutta niiden suorituskyky ei ole riitt\u00e4nyt koko laajaa taudinaiheuttajaryhm\u00e4\u00e4 ja suuresta mutaatioherkkyydest\u00e4 aiheutuvaa nopeaa resistenttien viruksien kehittymist\u00e4 vastaan. T\u00e4m\u00e4 pro gradu-tutkielma pyrkii tarjoamaan lyhyen esittelyn enteroviruksista ja syvemm\u00e4n tarkastelun niit\u00e4 vastaan kehitetyist\u00e4 antiviraaleista. T\u00e4m\u00e4 sis\u00e4lt\u00e4\u00e4 ensimm\u00e4isen\u00e4 kehitetyt kapsidiin sitoutuvat molekyylit, ei-rakenteellisia viruksen proteiineja vastaan suunnitellut antiviraalit sek\u00e4 virusinfektiossa hy\u00f6dynnettyj\u00e4 solun proteiineja est\u00e4v\u00e4t yhdisteet. Yhteenvetokappale pyrkii tarjoamaan ajatuksia kehitysty\u00f6n tulevaisuudesta ja alati l\u00e4henevist\u00e4 antienteroviraalisista hoidoista.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Enteroviruses have a major impact in today\u2019s world. They are responsible for a large portion of harmless infection but also cause life-threatening diseases, poliomyelitis being perhaps the best known example. Although vaccines have proven effective in the abolishment of polio, they cannot be considered as a final solution since they hold no effect on infections that are already taking place. For this, compounds inhibiting the proliferation of the viruses, antivirals, are needed. The research in search for such compounds against enteroviruses has been ongoing for decades, yet no drugs have been put to clinical use so far. Many potent antivirals have been made, a few of them going through clinical trials, but have always proven inefficacious against the diverse range of pathogens and their high mutation rate that provides quick resistance. This work aims to offer an introduction to the enteroviruses and an in depth coverage of many of the antivirals devised against them. This includes the prototype capsid binders, the antivirals created against the non-structural proteins of the viruses as well as the compounds inhibiting the cellular factors involved in the infection found quite recently. The concluding remarks aim to provide some insight to the future of the field and the approaching of antienteroviral treatments.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Ville Saarnio (vikasaar) on 2017-01-20 11:00:27.309857. Form: Pro gradu -lomake (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/pro-gradu-lomake). JyX data: [jyx_publishing-allowed (fi) =True]", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija.group@korppi.jyu.fi) on 2017-01-20T11:00:27Z\r\nNo. of bitstreams: 2\r\nURN:NBN:fi:jyu-201701201210.pdf: 1381206 bytes, checksum: 1a3c7ff478c3fe6e424c75d6266f5758 (MD5)\r\nlicense.html: 4792 bytes, checksum: f8b07f849adc66a238227dec983f9e2f (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2017-01-20T11:00:28Z (GMT). No. of bitstreams: 2\r\nURN:NBN:fi:jyu-201701201210.pdf: 1381206 bytes, checksum: 1a3c7ff478c3fe6e424c75d6266f5758 (MD5)\r\nlicense.html: 4792 bytes, checksum: f8b07f849adc66a238227dec983f9e2f (MD5)\r\n Previous issue date: 2017", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "1 verkkoaineisto (91 sivua)", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "antiviral", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Antiviral molecules of enteroviruses", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201701201210", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Kemian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Chemistry", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Orgaaninen kemia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Organic Chemistry", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.date.updated", "value": "2017-01-20T11:00:28Z", "language": "", "element": "date", "qualifier": "updated", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": "fi", "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4035", "language": null, "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "enterovirukset", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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