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[{"key": "dc.contributor.advisor", "value": "Siev\u00e4nen, Elina", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Majaharju, Silja", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2016-05-10T09:12:17Z", "language": "", "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2016-05-10T09:12:17Z", "language": "", "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2016", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.other", "value": "oai:jykdok.linneanet.fi:1532866", "language": null, "element": "identifier", "qualifier": "other", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/49697", "language": "", "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Tutkielman kirjallisessa osassa perehdyt\u00e4\u00e4n bisfosfonaatteihin, niiden ominaisuuksiin ja valmistukseen sek\u00e4 k\u00e4ytt\u00f6\u00f6n l\u00e4\u00e4ketieteess\u00e4. Bisfosfonaattien valmistuksessa perehdyt\u00e4\u00e4n sek\u00e4 itse bisfosfonaattien ett\u00e4 niiden johdannaisten valmistukseen.\r\n\r\nBisfosfonaattien ominaisuuksia k\u00e4yd\u00e4\u00e4n l\u00e4pi esitt\u00e4m\u00e4ll\u00e4 niiden kemiallisia, biokemiallisia sek\u00e4 farmakologisia ominaisuuksia ja vaikutustapoja. Eri bisfosfonaattien ominaisuuksia k\u00e4sittelev\u00e4t kappaleet on jaoteltu niist\u00e4 k\u00e4ytett\u00e4v\u00e4n sukupolvijaottelun mukaisesti. Bisfosfonaattien k\u00e4yt\u00f6ss\u00e4 p\u00e4\u00e4osassa ovat niiden l\u00e4\u00e4ketieteelliset sovellukset. \r\n\r\nBisfosfonaattien aihiol\u00e4\u00e4kkeiden valmistuksessa keskityt\u00e4\u00e4n happoryhm\u00e4n ester\u00f6intiin, amino- tai hydroksyyliryhm\u00e4n muokkaamiseen sek\u00e4 makromolekyylien tai l\u00e4\u00e4keaineiden konjugoimiseen bisfosfonaatteihin.7\r\n\r\nKokeellisen osan tavoitteena oli syntetisoida alendronaatin sappihappokonjugaatteja, bisfosfonaattien oraalisen biosaatavuuden parantamiseksi. Kun bisfosfonaatteja muokataan rasvaliukoisemmaksi, niiden imeytyminen ja turvallisuus parantuu. \r\n\r\nAluksi sappihapon karboksyyliryhm\u00e4 aktivoitiin muuttamalla se anhydridiksi. Anhydridin annettiin sitten reagoida natriumalendronaatin kanssa. Tavoitteena oli muodostaa amidisidos natriumalendronaatin aminoryhm\u00e4n ja sappihapon karboksyylihapon v\u00e4lille. Spektrien perusteella synteesien uskotaan onnistuneen, mutta t\u00e4ydellist\u00e4 varmuutta ei asiasta saatu.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Silja Majaharju (sitamaja) on 2016-05-10 09:12:17.022886. Form: Pro gradu -lomake (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/pro-gradu-lomake). JyX data: [jyx_publishing-allowed (fi) =True]", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija.group@korppi.jyu.fi) on 2016-05-10T09:12:17Z\r\nNo. of bitstreams: 2\r\nURN:NBN:fi:jyu-201605102463.pdf: 3274373 bytes, checksum: 374b1f23981022db6b57191ea12f1c60 (MD5)\r\nlicense.html: 4831 bytes, checksum: 3c2bdf99ee37c2b87dfb01bfd481ca3c (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2016-05-10T09:12:17Z (GMT). No. of bitstreams: 2\r\nURN:NBN:fi:jyu-201605102463.pdf: 3274373 bytes, checksum: 374b1f23981022db6b57191ea12f1c60 (MD5)\r\nlicense.html: 4831 bytes, checksum: 3c2bdf99ee37c2b87dfb01bfd481ca3c (MD5)\r\n Previous issue date: 2016", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "1 verkkoaineisto (97 sivua)", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "Bisfosfonaatit", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "l\u00e4\u00e4ketieteellinen k\u00e4ytt\u00f6", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "luusairaudet", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "aihiol\u00e4\u00e4kkeet", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "alendronaatti", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "sappihappokonjugaatti", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "orgaaninen kemia", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Bisfosfonaatit : valmistus, ominaisuudet ja l\u00e4\u00e4ketieteellinen k\u00e4ytt\u00f6", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201605102463", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Kemian laitos", "language": "fi", "element": "contributor", 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