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[{"key": "dc.contributor.advisor", "value": "Nokia, Miriam", "language": null, "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Nordling, Iida", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2016-03-02T08:22:04Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2016-03-02T08:22:04Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2014", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.other", "value": "oai:jykdok.linneanet.fi:1523656", "language": null, "element": "identifier", "qualifier": "other", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/48986", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Tutkielman aiheena oli perehty\u00e4 theta-aktiivisuuden muutoksiin dorsaalisessa hippokampuksessa sek\u00e4 striatumissa pelkoehdollistamisen aikana. Theta-oskillaatiot ovat tyyppillisi\u00e4 hippokampukselle ja tutkimuksen tarkoituksena oli saada aiemman teorian rinnalle tarkempaa tietoa siit\u00e4 mit\u00e4 hippokampuksessa ja striatumissa tapahtuu oppimisen aikana. Tutkimus toteutettiin pelkoehdollistamisasetelmaa k\u00e4ytt\u00e4en. Ehdottomana \u00e4rsykkeen\u00e4 toimi s\u00e4hk\u00f6isku ja ehdollisena \u00e4rsykkeen\u00e4 4kHz/70dB \u00e4\u00e4ni. Tutkimuksessa oli 14 Sprague-Dawley urosrottaa. Elektrodien avulla ker\u00e4tty tieto koottiin habituaation, klassisen pelkoehdollistamisen, vihje- ja kontekstitestien sek\u00e4 ekstinktio asetelmien aikana. Testit videoitiin ja rottien pelkok\u00e4ytt\u00e4ytymist\u00e4 mitattiin laskemalla aika, jonka rotat olivat j\u00e4hmettynein\u00e4 ehdollisen \u00e4rsykkeen j\u00e4lkeen. Theta-aktiivisuus oli korkeampaa ehdollistamisen aikana hippokampuksessa kuin striatumissa. Muuten testin aikana merkitt\u00e4vimm\u00e4t theta-aktiivisuus tason muutokset olivat dorsaalisessa hippokampuksessa habituaation aikana sek\u00e4 striatumissa ekstinktion aikana. Habituaation aikana hippokampuksessa ja ekstinktion aikana striatumissa theta-aktiivisuus oli ehdollisen \u00e4rsykkeen aikana matalampaa kuin ennen tai j\u00e4lkeen ehdollisen \u00e4rsykkeen. Theta-aktiivisuus oli ekstinktion aikana matalampaa hyvien oppijoiden ryhm\u00e4ss\u00e4 kuin huonojen oppijoiden ryhm\u00e4ss\u00e4. Theta-aktiivisuus on selv\u00e4sti hippokampukselle tyypillist\u00e4 aktiivisuutta ja erityisen merkitt\u00e4v\u00e4\u00e4 ennen ja j\u00e4lkeen ehdollisen \u00e4rsykkeen, mutta ei ehdollisen \u00e4rsykkeen aikana. Striatumin theta-aktiivisuudella saattaa olla merkityst\u00e4 ekstinktiolle. Kuten my\u00f6s aiemmissa tutkimuksissa on havaittu, theta-aktiivisuus on eritt\u00e4in tyypillist\u00e4 hippokampukselle oppimisen kannalta. Striatumissa aktiivisuus on v\u00e4h\u00e4isemp\u00e4\u00e4, mutta merkitt\u00e4v\u00e4\u00e4 mahdollisesti erityisesti pois-oppimisen aikana.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "The aim of this study was to investigate the changes in theta activity in dorsal hippocampus and striatum during fear conditioning. Theta oscillations are known to be typical for hippocampus and we wanted to get deeper information on what happens in hippocampus and striatum during fear conditioning and learning. Our unconditioned stimulus was an electric shock and the conditioned stimulus was a 4kHz/70dB tone. As our study subjects we had 14 Sprague-Dawley male rats. \nElectrodes were placed in the brains of the rats and information was gathered during habituation, classical conditioning, cue test, context test and extinction. Our experiments were video-taped and the fear response behaviour was analyzed by calculating the percentage of the time the rat spent frozen after the conditioned stimulus. Theta activity was higher in hippocampus than in striatum during fear conditioning. Otherwise the main changes in theta levels were in dorsal hippocampus during habituation and in striatum during extinction. During habituation in dorsal hippocampus\nand during extinction in striatum theta levels were lower during the conditioned stimulus than \nbefore of after the conditioned stimulus. Good and poor learners showed difference during \nextinction as the theta levels were lower among the good learner group. Theta activity is clearly typical for hippocampus and significant before and after the conditioned stimulus but not during the conditioned stimulus. Theta activity in striatum might play a more significant role in\nextinction. Like previous research has shown theta activity is greatly typical for hippocampus \nconcerning learning. In striatum theta activity levels are lower during learning but probably more significant during extinction.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Miia Hakanen (mihakane) on 2016-03-02 08:22:04.331239. Form: Admin-lomake opinn\u00e4ytteiden julkaisuun (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/admin-lomake-opinnaytteet). JyX data: [jyx_publishing-allowed (fi) =False]", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija.group@korppi.jyu.fi) on 2016-03-02T08:22:04Z\nNo. of bitstreams: 2\nURN:NBN:fi:jyu-201603021738.pdf: 584067 bytes, checksum: 317e805e5cdf98745b3c2fdb4f6bd943 (MD5)\nlicense.html: 107 bytes, checksum: a7d86e598caa500b1b433bbb9dc8ef1c (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2016-03-02T08:22:04Z (GMT). No. of bitstreams: 2\nURN:NBN:fi:jyu-201603021738.pdf: 584067 bytes, checksum: 317e805e5cdf98745b3c2fdb4f6bd943 (MD5)\nlicense.html: 107 bytes, checksum: a7d86e598caa500b1b433bbb9dc8ef1c (MD5)\n Previous issue date: 2014", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "1 verkkoaineisto (23 sivua)", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "pelkoehdollistaminen", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "hippokampus", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "striatum", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "theta-aktiivisuus", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Activity changes in dorsal hippocampus and ventral striatum during trace fear conditioning in rats", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201603021738", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, 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p\u00e4\u00e4sy\u00e4 on rajoitettu tekij\u00e4noikeussyist\u00e4. Aineisto on luettavissa Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6asemalta. Ks. https://kirjasto.jyu.fi/fi/tyoskentelytilat/laitteet-ja-tilat.", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "This material has a restricted access due to copyright reasons. It can be read at the workstation at Jyv\u00e4skyl\u00e4 University Library reserved for the use of archival materials: https://kirjasto.jyu.fi/en/workspaces/facilities.", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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