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[{"key": "dc.contributor.advisor", "value": "Nokia, Miriam", "language": null, "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Kullberg, Nina", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Tiri, Sonja", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2016-02-23T11:25:13Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2016-02-23T11:25:13Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2015", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.other", "value": "oai:jykdok.linneanet.fi:1523147", "language": null, "element": "identifier", "qualifier": "other", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/48907", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Tutkimuksemme tarkoituksena oli selvitt\u00e4\u00e4, miten hippokampuksen dentate poimun (dentate gyrus) alueella ilmentyvien dentate-piikkien stimulointi vaikuttaa oppimiseen rotilla. Aiemmin on tutkittu dentate-piikkien vaikutuksia hippokampuksen oskillaatioihin. Tutkimuksia, jotka olisivat keskittyneet tarkastelemaan dentate-piikkien yhteytt\u00e4 n\u00e4kyv\u00e4\u00e4n k\u00e4ytt\u00e4ytymiseen, on ollut vaikeampi l\u00f6yt\u00e4\u00e4. Tieto siit\u00e4, miten aivojen oskillaatiot ovat sidoksissa k\u00e4ytt\u00e4ytymiseen ja oppimiseen, on t\u00e4rke\u00e4\u00e4 tulevien sovellusten, kuten kuntoutuksen vuoksi. Aiheeseen liittyv\u00e4t tutkimukset voisivat tarjota t\u00e4rke\u00e4\u00e4 informaatiota rappeuttavista aivosairauksista, kuten Alzheimerin taudista.\n Tutkimuksessamme k\u00e4ytimme Wistar -rottia, jotka jaettiin kolmeen ryhm\u00e4\u00e4n: v\u00e4litt\u00f6m\u00e4n stimulaation, viiv\u00e4stetyn stimulaation ja kontrolliryhm\u00e4\u00e4n. Pelkoehdollistamisen j\u00e4lkeen v\u00e4litt\u00f6m\u00e4n stimulaation ja viiv\u00e4stetyn stimulaation ryhmille annettiin dentate-piikki riippuvaisia s\u00e4hk\u00f6isi\u00e4 stimulaatioita angular bundle -alueelle. S\u00e4hk\u00f6inen stimulaatio j\u00e4ljitteli voimakkuudeltaan luonnollista dentate-piikki\u00e4. V\u00e4litt\u00f6m\u00e4n stimulaation ryhm\u00e4 sai s\u00e4hk\u00f6\u00e4rsykkeen heti, kun dentate-piikki ilmestyi. Viiv\u00e4stetyn stimulaation ryhm\u00e4 sai s\u00e4hk\u00f6\u00e4rsykkeen 300-600 millisekuntia dentate-piikin ilmestymisen j\u00e4lkeen. Kontrolliryhm\u00e4lle ei annettu s\u00e4hk\u00f6\u00e4rsykett\u00e4. Konteksti- ja vihjetestit suoritettiin pelkoehdollistamisen j\u00e4lkeisen\u00e4 p\u00e4iv\u00e4n\u00e4 ja rottien j\u00e4hmettyminen mitattiin manuaalisesti j\u00e4lkeenp\u00e4in.\nRyhmien v\u00e4lill\u00e4 ei ilmennyt tilastollisesti merkitsevi\u00e4 eroja j\u00e4hmettymisess\u00e4 eli dentate- piikkien aikaisella stimuloinnilla tai viiv\u00e4stetysti esitetyll\u00e4 stimuloinnilla ei ollut vaikutusta oppimiseen. My\u00f6sk\u00e4\u00e4n dentate-piikkien yleisyys ei ennustanut j\u00e4hmettymist\u00e4 v\u00e4litt\u00f6m\u00e4n ja viiv\u00e4stetyn stimulaation ryhmiss\u00e4. Tulokset voivat johtua tutkimusasetelmasta tai siit\u00e4, ett\u00e4 dentate-piikeill\u00e4 ei ole vaikutusta rottien j\u00e4hmettymiseen. Dentate-piikkej\u00e4 koskevan v\u00e4h\u00e4isen tiedon vuoksi dentate-piikkien yhteyksi\u00e4 k\u00e4ytt\u00e4ytymiseen tulisi tutkia laajemmin erilaisin menetelmin.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "n this research our aim was to study the effects of a dentate spike stimulation on learning. Previous studies have investigated how the dentate spikes affect the oscillatory dynamics in a hippocampal formation, but we could not find earlier studies that had focused on how the dentate spikes are related to visible behaviour. The knowledge about how brain oscillations are related to behaviour and learning is important for future adaptations, for instance rehabilitation, but also can enable better understanding of degenerative brain diseases such as Alzheimer\u2019s disease.\n In this study we used male Wistar rats which were divided in three groups, in an immediate, a delay and a control group. After trace fear conditioning the immediate and the delay groups received the dentate spike contingent stimulation to angular bundle: the immediate group received stimulation simultaneously when the dentate spike was predicted to occur and the delay group received stimulation 300-600 ms after the dentate spike had occurred. The stimulation imitated the natural dentate spike. The control group did not receive any stimulation. The context test and cue test were performed the next day and the freezing of the rats were measured manually afterwards.\n The results did not show significant difference in freezing between groups, indicating that the dentate spike stimulation did not have an effect on learning. Also the frequency of the dentate spikes did not predict freezing in immediate and delay groups. This might be due to settings of our study or the possibility that the dentate spikes are not related to freezing behaviour in rats. Since little is known of the dentate spikes, the behavioral correlates could be studied with different settings. Also the effects of the dentate spikes to other brain oscillations should be studied more.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Miia Hakanen (mihakane) on 2016-02-23 11:25:13.203626. Form: Admin-lomake opinn\u00e4ytteiden julkaisuun (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/admin-lomake-opinnaytteet). JyX data: [jyx_publishing-allowed (fi) =False]", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija.group@korppi.jyu.fi) on 2016-02-23T11:25:13Z\nNo. of bitstreams: 2\nURN:NBN:fi:jyu-201602231663.pdf: 716773 bytes, checksum: b9d1039a439dd934dd65783efbb01d53 (MD5)\nlicense.html: 107 bytes, checksum: a7d86e598caa500b1b433bbb9dc8ef1c (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2016-02-23T11:25:13Z (GMT). No. of bitstreams: 2\nURN:NBN:fi:jyu-201602231663.pdf: 716773 bytes, checksum: b9d1039a439dd934dd65783efbb01d53 (MD5)\nlicense.html: 107 bytes, checksum: a7d86e598caa500b1b433bbb9dc8ef1c (MD5)\n Previous issue date: 2015", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "1 verkkoaineisto (34 sivua)", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.title", "value": "Effects of post-training hippocampal dentate spike - contingent stimulation on learning after trace fear conditioning in rats", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201602231663", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Yhteiskuntatieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Social Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Psykologian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Psychology", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psykologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psychology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.date.updated", "value": "2016-02-23T11:25:14Z", "language": null, "element": "date", "qualifier": "updated", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": null, "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "restrictedAccess", "language": "fi", "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "202", "language": null, "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "hippokampus", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "stimulointi", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "oppiminen", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "Aineistoon p\u00e4\u00e4sy\u00e4 on rajoitettu tekij\u00e4noikeussyist\u00e4. Aineisto on luettavissa Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6asemalta. Ks. https://kirjasto.jyu.fi/fi/tyoskentelytilat/laitteet-ja-tilat.", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "This material has a restricted access due to copyright reasons. It can be read at the workstation at Jyv\u00e4skyl\u00e4 University Library reserved for the use of archival materials: https://kirjasto.jyu.fi/en/workspaces/facilities.", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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