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[{"key": "dc.contributor.advisor", "value": "Nikander, Riku", "language": null, "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Ketolainen, Heini", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2015-10-21T16:23:28Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2015-10-21T16:23:28Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2015", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.other", "value": "oai:jykdok.linneanet.fi:1498237", "language": null, "element": "identifier", "qualifier": "other", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/47353", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Rintasy\u00f6p\u00e4 on naisten yleisin sy\u00f6p\u00e4 l\u00e4nsimaissa ja eniten sit\u00e4 esiintyy yli 60-vuotiailla. Postmenopausaalisen rintasy\u00f6v\u00e4n riskiin voidaan vaikuttaa fyysisen aktiivisuuden avulla. Fyysisen aktiivisuuden on aikaisemmissa tutkimuksissa todettu olevan yhteydess\u00e4 rintasy\u00f6p\u00e4riskiin siten, ett\u00e4 liikuntaa harrastavilla rintasy\u00f6p\u00e4riski on pienempi kuin v\u00e4h\u00e4n liikkuvilla. T\u00e4m\u00e4n ty\u00f6n tarkoituksena oli selvitt\u00e4\u00e4, onko fyysinen aktiivisuus yhteydess\u00e4 rintasy\u00f6v\u00e4n histologiseen erilaistumisasteeseen postmenopausaalisilla naisilla. Lis\u00e4ksi tutkittiin, mitk\u00e4 muut tekij\u00e4t ovat yhteydess\u00e4 rintasy\u00f6v\u00e4n histologiseen erilaistumisasteeseen. \n\nT\u00e4m\u00e4n poikkileikkaustutkimuksen aineistona on k\u00e4ytetty 12 kuukautta kest\u00e4neen satunnaistetun interventiotutkimuksen alkumittausaineistoa. Tutkittavat on jaettu kolmeen ryhm\u00e4\u00e4n rintasy\u00f6v\u00e4n erilaistumisasteen Nottingham-luokituksen perusteella. Tutkittavilta kysyttiin heid\u00e4n aiempaa fyysist\u00e4 aktiivisuuttaan koskevia kysymyksi\u00e4. Sekoittavina tekij\u00f6in\u00e4 analyyseiss\u00e4 huomioitiin ik\u00e4, paino, pituus, sosioekonominen asema, tupakointi, alkoholink\u00e4ytt\u00f6, kuukautisten alkamisik\u00e4, synnytysten m\u00e4\u00e4r\u00e4, vaihdevuosien alkamisik\u00e4, hormonikorvaushoidon k\u00e4ytt\u00f6 sek\u00e4 is\u00e4n ja \u00e4idin kuolinsyyt. N\u00e4iden tekij\u00f6iden yhteytt\u00e4 rintasy\u00f6v\u00e4n histologiseen erilaistumisasteeseen analysoitiin SPSS Statistics 22 \u2013ohjelmalla Spearmanin j\u00e4rjestyskorrelaatiokertoimen avulla. Rintasy\u00f6v\u00e4n erilaistumisasteen vaihtelua selitt\u00e4vi\u00e4 tekij\u00f6it\u00e4 analysoitiin ordinaalisen logistisen regressioanalyysin avulla. \n\nNuoruudessa ja aikuisuudessa aiemmin harrastettu fyysinen aktiivisuus ei ollut yhteydess\u00e4 postmenopausaalisen rintasy\u00f6v\u00e4n histologiseen erilaistumisasteeseen. Kun tutkittavien ik\u00e4, paino, pituus ja sosioekonominen asema oli vakioitu, painon ristitulosuhde oli tilastollisesti merkitsev\u00e4 (p=.038) verrattuna rintasy\u00f6v\u00e4n erilaistumisastemuuttujan kolmanteen luokkaan. Toisin sanoen lis\u00e4kilo painossa lis\u00e4si noin 2,4 % todenn\u00e4k\u00f6isyytt\u00e4 sairastaa lievemp\u00e4\u00e4 rintasy\u00f6v\u00e4n muotoa kuin kolmannen luokan sy\u00f6p\u00e4\u00e4. Kun oli vakioitu lis\u00e4ksi tupakointi, kuukautisten alkamisik\u00e4, synnytysten lukum\u00e4\u00e4r\u00e4, vaihdevuosien alkamisik\u00e4, hormonikorvaushoidon k\u00e4ytt\u00f6 sek\u00e4 is\u00e4n ja \u00e4idin kuolinsyy, my\u00f6s alkoholink\u00e4ytt\u00f6 oli tilastollisesti merkitsev\u00e4sti yhteydess\u00e4 erilaistumisasteeseen. Alkoholia korkeintaan kerran kuukaudessa k\u00e4ytt\u00e4v\u00e4t sairastivat 5.3 (95% CI 1.2-23.4) kertaa todenn\u00e4k\u00f6isemmin lievemp\u00e4\u00e4 rintasy\u00f6v\u00e4n muotoa, kuin kolmannen luokan sy\u00f6p\u00e4\u00e4, kun heit\u00e4 verrattiin viikoittain alkoholia k\u00e4ytt\u00e4viin. \n\nT\u00e4m\u00e4n tutkimuksen tulokset osoittivat, ett\u00e4 ik\u00e4vuosien 7-44 aikana harrastettu fyysinen aktiivisuus ei ollut yhteydess\u00e4 postmenopausaali-i\u00e4ss\u00e4 ilmenev\u00e4n rintasy\u00f6v\u00e4n histologiseen erilaistumisasteeseen. Sen sijaan pieni lis\u00e4paino ja erityisesti v\u00e4h\u00e4inen alkoholink\u00e4ytt\u00f6 n\u00e4yttiv\u00e4t suojaavan vakavalta rintasy\u00f6v\u00e4n muodolta.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Breast cancer is the most common cancer among women in Western countries. It is most common among women over 60 years of age. The risk of postmenopausal breast cancer can be affected by physical activity. It has been found in earlier studies that breast cancer is associated with physical activity and those who are physically active have lower breast cancer risk than those who are sedentary. The objective of this study was to investigate whether physical activity is associated with histologic grade of breast cancer and which factors explain the determination of histologic grade of breast cancer in postmenopausal women. \n\nThis cross-sectional study was based on the baseline data of a randomized controlled trial. Breast cancer surivors were divided into three separate groups according to Nottingham histological grade of breast cancer. In this study participants were asked questions concerning physical activity earlier in their life. Potential confounding factors such as age, weight, height, sosioeconomic status, smoking, drinking of alcohol, age at menarche, amount of childbirths, age at menopause, use of hormone replacement therapy and cause of death of father\u2019s and mother\u2019s were taken into account when analysing the data. Associations of the confounding factors with the histologic grade were analysed using the SPSS Statistics Spearman\u2019s rank correlation coefficient. Factors explaining determination of histologic grade were analysed with ordinal logistic regression analysis. \n\nFormer physical activity was not associated with histological grade of postmenopausal breast cancer. As the age, weight, height and socioeconomic status of the participants were controlled for, the odds ratio of weight was statistically significant (p=.038) compared with the category 3 of the histological grade. It means that an extra kilogram of gained weight increases the risk of belonging to a lower category of histologic grade by 2,4 percent. As smoking, drinking of alcohol, age at menarche, amount of childbirths, age at menopause, use of hormone replacement therapy and cause of death of father\u2019s and mother\u2019s were also controlled for, drinking of alcohol was statistically significantly associated with the histological grade. Those who drank alcohol, but at most once a month had a 5.3-fold (95% CI 1.2-23.4) risk of belonging to a lower category of histological grade compared to those who drank alcohol at least once a week. \n\nThe results of this cross-sectional study indicate that physical activity during seven to 44 years of age is not associated with the histological grade of postmenopausal breast cancer. However, an extra weight seemed to be associated with milder histological breast cancer grade and low alcohol consumption was clearly associated with milder breast cancer type.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Heini Ketolainen (hemakake) on 2015-10-21 16:23:28.290432. Form: Pro gradu -lomake (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/pro-gradu-lomake). JyX data: [jyx_publishing-allowed (fi) =True]", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija.group@korppi.jyu.fi) on 2015-10-21T16:23:28Z\nNo. of bitstreams: 2\nURN:NBN:fi:jyu-201510213445.pdf: 791283 bytes, checksum: 47ae1ab5eb19204c63f3a2d461850cae (MD5)\nlicense.html: 4859 bytes, checksum: 367c1cd9b51e682280ce61ca669ce8e2 (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2015-10-21T16:23:28Z (GMT). No. of bitstreams: 2\nURN:NBN:fi:jyu-201510213445.pdf: 791283 bytes, checksum: 47ae1ab5eb19204c63f3a2d461850cae (MD5)\nlicense.html: 4859 bytes, checksum: 367c1cd9b51e682280ce61ca669ce8e2 (MD5)\n Previous issue date: 2015", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "1 verkkoaineisto (53 sivua)", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "Postmenopausaalinen rintasy\u00f6p\u00e4", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "fyysinen aktiivisuus", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "histologinen erilaistumisaste", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Fyysisen aktiivisuuden yhteys rintasy\u00f6v\u00e4n erilaistumisasteeseen postmenopausaalisilla naisilla", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201510213445", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": 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