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[{"key": "dc.contributor.advisor", "value": "V\u00e4lisaari, Jouni", "language": null, "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Eriksson, Terhi", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2015-10-21T12:34:34Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2015-10-21T12:34:34Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2015", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.other", "value": "oai:jykdok.linneanet.fi:1498229", "language": null, "element": "identifier", "qualifier": "other", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/47346", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4ss\u00e4 Pro gradu -tutkielmassa on suunniteltu l\u00e4\u00e4keaineanalytiikan opetusmateriaalia\r\nlaboratorioalan ammatillisen koulutuksen valinnaisiin opintoihin. Kirjallisuusosaan on\r\nkoottu tietoja tulehduskipul\u00e4\u00e4kkeist\u00e4, niiden sitoutumisesta plasman proteiineihin sek\u00e4\r\nl\u00e4\u00e4keainepitoisuuden analysoinnista ja menetelm\u00e4n validoinnista. Analysoinnissa on\r\nkeskitytty erilaisiin plasman proteiinien erotustapoihin ja n\u00e4ytteen derivatisointiin.\r\nAnalyysilaitteistoina olevista kaasu- ja nestekromatografeista on kirjallisuusosaan ker\u00e4tty\r\noleellisimmat tiedot. Menetelm\u00e4n validointia on k\u00e4sitelty l\u00e4ht\u00f6kohtaisesti biologisten\r\nn\u00e4ytteiden kannalta. Kirjallisuusosaan on ker\u00e4tty tietoja, joita voi k\u00e4ytt\u00e4\u00e4 teoriaopetuksen\r\npohjana. Ne my\u00f6s tukevat tiiviisti kokeellisen osan harjoitust\u00f6it\u00e4.\r\nKokeellisessa osassa on kartoitettu kirjallisuudesta l\u00f6ytyvi\u00e4 analyysimenetelmi\u00e4\r\ntulehduskipul\u00e4\u00e4kkeille. Tutkimukseen on valittu mukaan sek\u00e4 biologisille\r\nplasman\u00e4ytteille ett\u00e4 apteekin valmisteille soveltuvia analyysimenetelmi\u00e4. T\u00e4rke\u00e4 kriteeri\r\nanalyysimenetelmi\u00e4 ja harjoitust\u00f6it\u00e4 valittaessa on ollut, ett\u00e4 ne soveltuvat ammatillisen\r\nkoulutuksen opetuslaboratorioihin.\r\nT\u00e4ss\u00e4 tutkimuksessa on kehitetty kolme erilaista harjoitusty\u00f6t\u00e4 tulehduskipul\u00e4\u00e4kkeiden\r\npitoisuuksien m\u00e4\u00e4rityksest\u00e4. Harjoitusty\u00f6t on valittu siten, ett\u00e4 ne eroavat toisistaan\r\nriitt\u00e4v\u00e4sti, opettavat l\u00e4\u00e4keaineanalytiikkaa mahdollisimman laajasti ja soveltuvat\r\nammatillisen koulutuksen laboratorio-opetukseen. Tulehduskipul\u00e4\u00e4kkeiksi on valittu\r\nibuprofeeni, indometasiini ja ketoprofeeni. T\u00e4h\u00e4n tutkimukseen valittujen harjoitust\u00f6iden\r\nanalysointi perustuu kaasu- ja nestekromatografisiin menetelmiin. Detektoreina niiss\u00e4 on\r\nk\u00e4yt\u00f6ss\u00e4 massa-, UV- ja UV-vis \u2013detektorit. Massadetektorilla on k\u00e4yt\u00f6ss\u00e4 sek\u00e4\r\nnegatiivinen kemiallinen ionisaatio ett\u00e4 s\u00e4hk\u00f6sumutus.\r\nT\u00e4h\u00e4n tutkimukseen koottu opetusmateriaali monipuolistaa ammatillisen koulutuksen\r\nlaboranttiopiskelijoiden ammattitaitoa ja \u2013tietoutta. Plasman\u00e4ytteiden k\u00e4sittely sek\u00e4\r\nkromatografisten tietojen ja taitojen soveltaminen l\u00e4\u00e4keaineanalytiikkaan vahvistavat\r\nopiskelijoiden osaamista laboratorioty\u00f6skentelyss\u00e4 ja biologisten n\u00e4ytteiden k\u00e4sittelyss\u00e4.", "language": "", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Terhi Eriksson (tetusalo) on 2015-10-21 12:34:33.832909. Form: Pro gradu -lomake (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/pro-gradu-lomake). JyX data: [jyx_publishing-allowed (fi) =True]", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija.group@korppi.jyu.fi) on 2015-10-21T12:34:34Z\nNo. of bitstreams: 2\nURN:NBN:fi:jyu-201510213440.pdf: 587722 bytes, checksum: 07d5efbedffc32be291393170df7a1af (MD5)\nlicense.html: 4854 bytes, checksum: f8b2a43375a16a516c67a0c0f19e282f (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2015-10-21T12:34:34Z (GMT). No. of bitstreams: 2\nURN:NBN:fi:jyu-201510213440.pdf: 587722 bytes, checksum: 07d5efbedffc32be291393170df7a1af (MD5)\nlicense.html: 4854 bytes, checksum: f8b2a43375a16a516c67a0c0f19e282f (MD5)\n Previous issue date: 2015", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "1 verkkoaineisto (60 sivua)", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.title", "value": "L\u00e4\u00e4keaineanalytiikan oppimateriaalin kehitt\u00e4minen ammatilliseen laboratorioalan koulutukseen", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201510213440", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Kemian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Chemistry", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Kemian opettajankoulutus", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Teacher education programme in Chemistry", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.date.updated", "value": "2015-10-21T12:34:34Z", "language": null, "element": "date", "qualifier": "updated", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": null, "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": "fi", "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4034", "language": null, "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "tulehduskipul\u00e4\u00e4kkeet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "oppimateriaali", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "l\u00e4\u00e4keaineet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "ammatillinen koulutus", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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