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[{"key": "dc.contributor.advisor", "value": "Tuhkanen, Tuula", "language": null, "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Ngumba, Elijah", "language": null, "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Kosunen, P\u00e4ivi", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2015-06-23T05:59:16Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2015-06-23T05:59:16Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2015", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.other", "value": "oai:jykdok.linneanet.fi:1476494", "language": null, "element": "identifier", "qualifier": "other", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/46388", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Antibioottien havaitseminen j\u00e4tevesist\u00e4 on haastavaa johtuen matalista pitoisuuksista ja monimutkaisesta matriisista. T\u00e4ss\u00e4 ty\u00f6ss\u00e4 kehiteltiin kiinte\u00e4faasiuuttoa, nestekromatografia ja tandem massaspektrometri\u00e4 hyv\u00e4ksi k\u00e4ytt\u00e4v\u00e4 menetelm\u00e4, jolla voitiin analysoida viitt\u00e4 antibioottia yht\u00e4aikaisesti matalina pitoisuuksina j\u00e4tevesist\u00e4, ja sit\u00e4 testattiin k\u00e4yt\u00e4nn\u00f6ss\u00e4 kolmen keskisuuren suomalaisen j\u00e4tevedenpuhdistamon j\u00e4tevesiin. \nMonimutkainen matriisi heikent\u00e4\u00e4 usein antibioottien signaalia massaspektrometriss\u00e4 ja t\u00e4ss\u00e4 ty\u00f6ss\u00e4 k\u00e4ytettiin matriisi-korjattua ulkoista standardia huomioimaan efekti\u00e4. Mene-telm\u00e4 oli yksinkertainen, nopea ja toistettava. M\u00e4\u00e4ritysrajat vaihtelivat <10\u2013150 ng/l v\u00e4lill\u00e4. Viidest\u00e4 tutkitusta antibiootista kolmea (trimetopriimi, sulfametoksatsoli ja siprofloksasiini) havaittiin kaikissa tutkituissa puhdistamattomissa j\u00e4tevesiss\u00e4. Doksisykliini\u00e4 ja nor-floksasiinia ei havaittu j\u00e4tevesiss\u00e4 lainkaan. Korkein havaittu pitoisuus oli siprofloksasii-nilla, 300 ng/L. Pitoisuudet olivat samaa luokkaa kuin mit\u00e4 aiemmin tutkimuksissa on ha-vaittu. Ainoastaan trimetopriimi\u00e4 havaittiin puhdistetuissa j\u00e4tevesiss\u00e4, ja sen pitoisuus oli korkeampi jokaisessa tutkitussa puhdistetussa j\u00e4tevedess\u00e4 kuin puhdistamattomassa. T\u00e4m\u00e4 johtunee siit\u00e4, ett\u00e4 vain v\u00e4h\u00e4n muuntuneet aineenvaihduntatuotteet voivat muuntua takaisin alkuper\u00e4isiksi l\u00e4\u00e4keaineiksi j\u00e4teveden puhdistusprosessin aikana. Mikrobil\u00e4\u00e4kkeit\u00e4 on suuri m\u00e4\u00e4r\u00e4 eik\u00e4 niit\u00e4 kaikkia voi tutkia yht\u00e4 aikaisesti j\u00e4tevesist\u00e4. Jatkotutkimuksia tarvitaankin, jotta l\u00f6ydet\u00e4\u00e4n indikaattoriyhdisteet, joita voidaan analysoida yht\u00e4aikaisesti ja joiden avulla voidaan m\u00e4\u00e4ritell\u00e4 mikrobil\u00e4\u00e4kkeiden aiheuttama resistenttien kantojen riski.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "The detection of antibiotics in wastewater is a challenge due low concentration and com-plex matrix. In this work the method with solid phase extraction, liquid chromatography and tandem mass spectrometry was developed to analyze five antibiotics simultaneously in wastewaters. The method was applied in practice by measuring concentration of antibiotics in three Finnish medium size WWTPs.\nComplex matrix can suppress the signal of antibiotics in mass spectrometry and this was taken into account by using matrix matched external standard. The developed method was simple, fast and repeatable and the limit of detections range from <10\u2013150 ng/L. Three of five antibiotics (trimethoprim, sulfamethoxazole and ciprofloxacin) were detected in all influents. Doxycycline and norfloxacin were not detected neither influents nor effluents. In influent ciprofloxacin had the highest concentration: 300 ng/L. The concentrations were similar to published studies. Trimethoprim was the only one detected in effluents, and the concentrations were higher in all effluents than in influents. This may be because slightly transformed metabolites can be transformed back to parent compounds during the treat-ment process. As there are large amount of different antimicrobials in wastewaters and all of them cannot be detected at the same time, further investigate is needed to find the indi-cate compounds that can be detected simultaneously and assess the risk of antimicrobial resistance.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by P\u00e4ivi Kosunen (pahejaak) on 2015-06-23 05:59:16.020574. Form: Pro gradu -lomake (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/pro-gradu-lomake). JyX data: [jyx_publishing-allowed (fi) =True]", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija.group@korppi.jyu.fi) on 2015-06-23T05:59:16Z\nNo. of bitstreams: 2\nURN:NBN:fi:jyu-201506232410.pdf: 1273000 bytes, checksum: 8f4d2c21151437eb7ddb89505c8d82ca (MD5)\nlicense.html: 4849 bytes, checksum: 0106e729db15fb91c9d6cecab4cea25b (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2015-06-23T05:59:16Z (GMT). No. of bitstreams: 2\nURN:NBN:fi:jyu-201506232410.pdf: 1273000 bytes, checksum: 8f4d2c21151437eb7ddb89505c8d82ca (MD5)\nlicense.html: 4849 bytes, checksum: 0106e729db15fb91c9d6cecab4cea25b (MD5)\n Previous issue date: 2015", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "1 verkkoaineisto (51 sivua)", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "kiinte\u00e4afaasiuutto", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Simultaneous determination of five antibiotics in urban wastewater using SPE-HPLC-MS/MS", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201506232410", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Bio- ja ymp\u00e4rist\u00f6tieteiden laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Biological and Environmental Science", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Ymp\u00e4rist\u00f6tiede ja -teknologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Environmental science and technology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.date.updated", "value": "2015-06-23T05:59:17Z", "language": null, "element": "date", "qualifier": "updated", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": null, "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": "fi", "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4015", "language": null, "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "antibiootit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "l\u00e4\u00e4keaineet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "suuren erotuskyvyn nestekromatografia", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "j\u00e4tevesi", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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