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[{"key": "dc.contributor.author", "value": "Rintala, Aki", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2015-05-20T10:13:24Z", "language": "", "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2015-05-20T10:13:24Z", "language": "", "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2015", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.other", "value": "oai:jykdok.linneanet.fi:1473950", "language": null, "element": "identifier", "qualifier": "other", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/45961", "language": "", "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4m\u00e4n pro gradu\u2013tutkielman tarkoituksena oli selvitt\u00e4\u00e4 MS-tautia sairastavien terveyteen liittyv\u00e4n el\u00e4m\u00e4nlaadun muutosta 10 vuoden seurannassa sek\u00e4 tutkia sosiodemografisten ja kliinisten tekij\u00f6iden yhteytt\u00e4 terveyteen liittyv\u00e4\u00e4n el\u00e4m\u00e4nlaatuun geneerisill\u00e4 ja sairausspesi-fill\u00e4 el\u00e4m\u00e4nlaatumittareilla.\r\nTutkimukseen osallistui 109 k\u00e4velev\u00e4\u00e4 MS-tautia sairastavaa henkil\u00f6\u00e4 vuonna 2002, josta 77 (70.6 %) henkil\u00f6\u00e4 osallistui seurantatutkimukseen vuonna 2012. Tutkittavista 79 % oli naisia keski-i\u00e4n ollessa 48 (SD 10.4) vuotta. Tutkittavista 90 % sairasti aaltomaisesti tai sekundaari-sesti etenev\u00e4\u00e4 tautityyppi\u00e4 ja 8 % ensisijaisesti etenev\u00e4\u00e4 MS-tautia. Sairauden kesto tutkimuk-sen lopputilanteessa oli 20 (SD 6.6) vuotta. Terveyteen liittyv\u00e4\u00e4 el\u00e4m\u00e4nlaatua tarkasteltiin yleisill\u00e4 36-Item Short Form Survey Instrument- (RAND-36), 15D-instrument- (15D) ja sai-rausspesifill\u00e4 Multiple Sclerosis Quality of Life-54- (MSQOL-54) kyselyill\u00e4. Sairauden vai-keusaste m\u00e4\u00e4riteltiin alkutilanteessa neurologin tekem\u00e4n\u00e4 EDSS-asteikolla (Expanded Disabi-lity Status Scale) ja lopputilanteessa osallistujien itsearvioituna SDSS-asteikolla (Subjective Expanded Disability Status Scale). El\u00e4m\u00e4nlaadun muutosta tarkasteltiin toistomittauksen va-rianssianalyysilla (MANOVA) ja muutoksen voimakkuutta (ES) efektikoolla (Cohen d). So-siodemografisten ja kliinisten tekij\u00f6iden yhteytt\u00e4 el\u00e4m\u00e4nlaatuun tarkasteltiin lineaarisella reg-ressioanalyysilla.\r\nTerveyteen liittyv\u00e4 el\u00e4m\u00e4nlaatu heikkeni RAND-36:n fyysisiss\u00e4 yhdistelm\u00e4pisteiss\u00e4 (p=.003, ES 0.26) ja 15D:n kokonaisindeksiss\u00e4 (p=.012, ES 0.22). El\u00e4m\u00e4nlaatu heikkeni my\u00f6s RAND-36:n fyysisess\u00e4 toimintakyvyn (p=.001, ES 0.27), kivuttomuuden (p=.020, ES 0.25) ja koetun terveyden (p=.002, ES 0.36), MSQOL-54:n fyysisen toimintakyvyn (p=.001, ES 0.27), kivuttomuuden (p=.040, ES 0.21), seksuaalisen toimintakyvyn (p=.003, ES 0.43) ja tyytyv\u00e4isyydess\u00e4 seksuaalisen toimintakyvyn (p=.012, ES 0.38) ulottuvuuksissa, sek\u00e4 15D:n liikkumisen (p=.004, ES 0.34) ja seksuaalisen toimintakyvyn (p=<.001, ES 0.61) osioissa. El\u00e4m\u00e4nlaatu parani RAND-36:n sosiaalisessa toimintakyvyss\u00e4 (p=.049, ES 0.25). Muissa el\u00e4m\u00e4nlaadun yhdistelm\u00e4pisteiss\u00e4, ulottuvuuksissa tai osioissa muutosta ei esiintynyt. Korkeampi el\u00e4m\u00e4nlaatu RAND-36:n (p=<.001) ja MSQOL-54:n (p=.007) fyysisiss\u00e4 yhdistelm\u00e4pisteiss\u00e4 ja 15D:n kokonaisindeksiss\u00e4 (p=.013) oli yhteydess\u00e4 lievemp\u00e4\u00e4n sairauden vaikeusasteen (EDSS 0.0\u20133.5). Korkea el\u00e4m\u00e4nlaatu RAND-36:n (p=<.031) ja MSQOL-54:n (p=<.016) psyykkisiss\u00e4 yhdistelm\u00e4pisteiss\u00e4 oli yhteydess\u00e4 pidemp\u00e4\u00e4n sairauden kestoon ja sukupuoli (naiset) oli yhteydess\u00e4 korkeaan el\u00e4m\u00e4nlaatuun 15D:n kokonaisindeksiss\u00e4 (p=.046). Heikko el\u00e4m\u00e4nlaatu MSQOL-54 psyykkisiss\u00e4 yhdistelm\u00e4pisteiss\u00e4 (p=.026) oli yhteydess\u00e4 korkeaan ik\u00e4\u00e4n.\r\nKymmenen vuoden seurannassa MS-tautia sairastavien henkil\u00f6iden fyysiseen terveyteen liit-tyv\u00e4 el\u00e4m\u00e4nlaatu heikkeni enemm\u00e4n kuin psyykkiseen terveyteen liittyv\u00e4 el\u00e4m\u00e4nlaatu riippumatta el\u00e4m\u00e4nlaatumittarista. Sosiodemografisilla ja kliinisill\u00e4 tekij\u00f6ill\u00e4 oli yhteytt\u00e4 terveyteen liittyv\u00e4\u00e4n el\u00e4m\u00e4nlaatuun. Pitk\u00e4aikaisia v\u00e4est\u00f6\u00f6n pohjautuvia el\u00e4m\u00e4nlaatututkimuksia kaivataan MS-tautia sairastavien el\u00e4m\u00e4nlaadun muutosherkkyyden arvioimiseen.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "The aim of this 10 year follow-up study was to determine the change in health-related quality of life (HRQoL) over time in persons with MS (PwMS) using generic and disease-specific measure and to explore the associations between sociodemographic and clinical factors with HRQoL.\r\nIn this study 109 ambulatory PwMS participated in 2002 of whom 77 (70.6 %) were re-assessed in 2012. In follow-up there were 61 (79.2 %) females and participants mean (SD) age was 48.0 (10.4) years. Ninety percent (90 %) of the participants had primary remitting MS including both relapsing-remitting and secondary-progressive MS and 8 % had primary progressive MS. The mean (SD) disease duration at follow-up was 20.0 (6.6) years. HRQoL was determined using generic 36-Item Short Form Survey Instrument (RAND-36), 15D- and disease-specific Multiple Sclerosis Quality of Life-54 (MSQOL-54) instruments. Neurologist assessed EDSS (Expanded Disability Status Scale) in the baseline and participants used SDSS (Subjective Expanded Disability Status Scale) in 10-year assessment. Repeated measures ANOVA and effect size (ES) calculations (Cohen\u2019s d) were used in statistical analysis. Asso-ciations were analyzed with multiple linear regression using the HRQoL composite and total scores as dependent variables.\r\nRAND-36 physical composite score (PCS) (p=.003, ES 0.26) and 15D total score (p=.012, ES 0.22) deteriorated. Deterioration occurred in RAND-36 physical functioning (p=.001, ES 0.27), pain (p=.020, ES 0.25) and general health perceptions (p=.002, ES 0.36), in MSQOL-54 physical function (p=.001, ES 0.27), pain (p=.040, ES 0.21), sexual function (p=.003, ES 0.43) and satisfaction with sexual function (p=.012, ES 0.38) scales, and in 15D mobility (p=.004, ES 0.34) and sexual function (p=<.001, ES 0.61) dimensions. Improvement was shown in RAND-36 social functioning (p=.049, ES 0.25). Other composite scores, scales and dimensions in HRQoL measures remained unchanged. Physical disability between EDSS 0.0\u20133.5 at the baseline was associated with higher HRQoL in RAND-36 PCS (p=<.001), MSQOL-54 physical health composite (PHC) (p=.007) and 15D total score (p=.013) in the follow-up. Longer disease duration was associated with higher HRQoL in RAND-36 mental composite (MCS) (p=<.031) and MSQOL-54 mental health composite scores (MHC) (p=.016). Higher age was associated with lower HRQoL in MSQOL-54 MHC (p=.026) and gender (female) with higher HRQoL in 15D total score (p=.046).\r\nThe results of the present study suggest that the deterioration in HRQoL among ambulatory PwMS focuses more in physical than mental function regardless of the outcome measure in the 10-year follow-up. Sociodemographic and clinical factors was associated with HRQoL. More long-term population based studies are needed to determine the sensitivity to change in HRQoL among persons with MS.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Miia Hakanen (mihakane) on 2015-05-20 10:13:24.024428. Form: Admin-lomake opinn\u00e4ytteiden julkaisuun (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/admin-lomake-opinnaytteet). JyX data: [jyx_publishing-allowed (fi) =False]", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija@noreply.fi) on 2015-05-20T10:13:24Z\r\nNo. of bitstreams: 2\r\nURN:NBN:fi:jyu-201505201917.pdf: 601754 bytes, checksum: 1ae6b4cb224388c6a8b5b9fd1b0d86b9 (MD5)\r\nlicense.html: 107 bytes, checksum: a7d86e598caa500b1b433bbb9dc8ef1c (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2015-05-20T10:13:24Z (GMT). No. of bitstreams: 2\r\nURN:NBN:fi:jyu-201505201917.pdf: 601754 bytes, checksum: 1ae6b4cb224388c6a8b5b9fd1b0d86b9 (MD5)\r\nlicense.html: 107 bytes, checksum: a7d86e598caa500b1b433bbb9dc8ef1c (MD5)\r\n Previous issue date: 2015", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "1 verkkoaineisto (58 sivua)", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "MS-tauti", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "multippeliskleroosi", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "el\u00e4m\u00e4nlaatu", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "terveyteen liittyv\u00e4 el\u00e4m\u00e4nlaatu", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "El\u00e4m\u00e4nlaadun muutokset multippeliskleroosia (MS) sairastavilla henkil\u00f6ill\u00e4 kymmenen vuoden seurannassa", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201505201917", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Liikuntatieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Terveystieteiden laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Health Sciences", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Fysioterapia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Physiotherapy", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.date.updated", "value": "2015-05-20T10:13:25Z", "language": "", "element": "date", "qualifier": "updated", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "restrictedAccess", "language": "fi", "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "50422", "language": null, "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "MS-tauti", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "el\u00e4m\u00e4nlaatu", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "terveys", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "Aineistoon p\u00e4\u00e4sy\u00e4 on rajoitettu tekij\u00e4noikeussyist\u00e4. Aineisto on luettavissa Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6asemalta. Ks. https://kirjasto.jyu.fi/fi/tyoskentelytilat/laitteet-ja-tilat.", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "This material has a restricted access due to copyright reasons. It can be read at the workstation at Jyv\u00e4skyl\u00e4 University Library reserved for the use of archival materials: https://kirjasto.jyu.fi/en/workspaces/facilities.", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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