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[{"key": "dc.contributor.advisor", "value": "Mikonranta, Lauri", "language": null, "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Mappes, Johanna", "language": null, "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Kaukoniitty, Minna", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2014-12-07T14:23:41Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2014-12-07T14:23:41Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2014", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.other", "value": "oai:jykdok.linneanet.fi:1453265", "language": null, "element": "identifier", "qualifier": "other", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/44823", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Hy\u00f6nteisiin lukeutuu monia merkitt\u00e4vi\u00e4 tuholaisia, taudinv\u00e4litt\u00e4ji\u00e4 ja hy\u00f6dyllisi\u00e4 lajeja, mink\u00e4 takia hy\u00f6nteisten taudit, taudinaiheuttajat ja immuunipuolustus ovat ekologisesta, ekonomisesta ja l\u00e4\u00e4ketieteellisest\u00e4 n\u00e4k\u00f6kulmasta t\u00e4rkeit\u00e4 tutkimuskohteita. Viimeaikaiset tutkimukset paljastavat hy\u00f6nteisten ja muiden selk\u00e4rangattomien immuunij\u00e4rjestelmien pystyv\u00e4n erikoistumaan ja luomaan pitk\u00e4kestoista immuniteettia. J\u00e4lkimm\u00e4inen ilmi\u00f6 tunnetaan tieteellisiss\u00e4 artikkeleissa nimell\u00e4 \u201dimmunological priming\u201d, jonka voisi k\u00e4\u00e4nt\u00e4\u00e4 suomeksi esimerkiksi \u201dimmuunipohjustukseksi\u201d. Immuunipohjustus on muistinkaltaista vastustuskyky\u00e4, joka auttaa elimist\u00f6\u00e4 puolustautumaan tehokkaammin toistuvia tartuntoja vastaan. Taudinaiheuttajan laukaisemat immuunitoiminnot voivat altistuksen j\u00e4lkeen pysy\u00e4 jonkin aikaa aktiivisina, ja pienent\u00e4\u00e4 n\u00e4in my\u00f6hemm\u00e4n tartunnan riski\u00e4. Mik\u00e4li tartuntariski on t\u00e4ll\u00f6in pienempi samanlaista kuin erilaista taudinaiheuttajaa kohtaan, on immuunipohjustus erikoistunutta. Erikoistuneisuuden havainnollistamiseksi on osoitettava, ett\u00e4 immuunipohjustuksen on aktivoinut sen kohteena oleva taudinaiheuttaja. T\u00e4ss\u00e4 tutkimuksessa selvitettiin erikoistuneen immuunipohjustuksen mahdollista ilmenemist\u00e4 t\u00e4pl\u00e4siilikk\u00e4\u00e4n (Parasemia plantaginis) toukkien kahdessa per\u00e4kk\u00e4isess\u00e4 altistuksessa samalle tai erilaisille Gram-negatiivisille bakteereille. Koebakteereina k\u00e4ytettiin kahta Serratia marcescens -kantaa, joista Db11-kanta on tunnettu hy\u00f6nteisten taudinaiheuttaja, ja ATCC#13880 ymp\u00e4rist\u00f6st\u00e4 eristetty kanta. Kontrollibakteerina k\u00e4ytettiin taudinaiheuttamiskyvyt\u00f6nt\u00e4 Escherichia coli K12 -kantaa. Toukat altistettiin bakteereille ensin oraalisesti ravinnon v\u00e4lityksell\u00e4, ja viisi p\u00e4iv\u00e4\u00e4 my\u00f6hemmin injektiolla. Oraalisessa altistuksessa Db11-kannan havaittiin olevan kahta muuta bakteeria huomattavasti virulentimpi. Vaikka Db11 osoittautui tutkimuksen tarkoituksen kannalta liian virulentiksi, immuunipohjustusta havaittiin toukilla, jotka oli oraalisesti altistettu ja injektoitu ATCC#13880-kannalla, kun niiden selviytymist\u00e4 verrattiin toukkiin, jotka oli altistettu E. coli:lla. Koska E. coli -altistus ei suojannut toukkia ATCC#13880-injektiota vastaan, voitiin immuunipohjustuksen p\u00e4\u00e4tell\u00e4 olevan ATCC#13880-kannalle erikoistunutta. Tutkimuksemme osoitti selk\u00e4rangattomien immuunij\u00e4rjestelm\u00e4n kyvyn erottaa erilaisia Gram-negatiivisia bakteereja toisistaan immuunipohjustuksen yhteydess\u00e4.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Insects have various important roles as pests, disease vectors and beneficial species, which make insect diseases, pathogens and immune responses important study areas not only from ecological but also from economical and medical point of view. Recent studies have revealed remarkable specificity and long-lasting immunity in insect and other invertebrate immune systems. A phenomenon called \u2018immunological priming\u2019 produces memory-like immune response, which help the host to fight against recurrent infections. Immune functions induced by a pathogen can remain enhanced for a period of time after the immune challenge, reducing the risk of re-infection. If the reduced risk relates more clearly to a similar than a different kind of pathogen, the immune response is considered to be specific. In order to demonstrate specificity in immunological priming, it is necessary to show that the priming was induced by the targeted pathogen. The aim of this study was to find out whether or not the wood tiger moth (Parasemia plantaginis) larvae show specific immunological priming after two consecutive immune challenges with the same or different Gram-negative bacteria. The experimental bacteria were two Serratia marcescens strains, a common insect pathogen Db11 and an environmental isolate ATCC#13880. The control bacterium was a non-pathogenic Escherichia coli K12 strain. The larvae were challenged in oral exposure and by injection. Db11 appeared to be considerably more virulent in oral exposure than the other two bacteria. Although Db11 proved to be too virulent for the main purpose of the study, immunological priming was observed in a group of larvae that had been orally exposed and five days later injected with ATCC#13880 in comparison to a group of larvae with prior E. coli exposure. Since the prior E. coli exposure did not provide protection against ATCC#13880 injection, the priming could be regarded as specific to ATCC#13880. This study demonstrated the ability of the invertebrate immune system to discriminate between different Gram-negative bacteria in the context of immunological priming.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Minna Kaukoniitty (mijokauk) on 2014-12-07 14:23:41.255900. Form: Pro gradu -lomake (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/pro-gradu-lomake). JyX data: [jyx_publishing-allowed (fi) =True]", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija@noreply.fi) on 2014-12-07T14:23:41Z\nNo. of bitstreams: 2\nURN:NBN:fi:jyu-201412073439.pdf: 603294 bytes, checksum: 9a96215993680f736c04b9b33e8ce25f (MD5)\nlicense.html: 4832 bytes, checksum: a750eb4b0c0a1cc58f713b3ad8f35ef1 (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2014-12-07T14:23:41Z (GMT). No. of bitstreams: 2\nURN:NBN:fi:jyu-201412073439.pdf: 603294 bytes, checksum: 9a96215993680f736c04b9b33e8ce25f (MD5)\nlicense.html: 4832 bytes, checksum: a750eb4b0c0a1cc58f713b3ad8f35ef1 (MD5)\n Previous issue date: 2014", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "1 verkkoaineisto (33 sivua)", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "adaptive immunity", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "innate immune system", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "insect herbivore", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "Lepidoptera", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "Serratia marcescens", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "within generational immune priming", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Immunological priming in the wood tiger moth (Parasemia plantaginis)", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201412073439", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Bio- ja ymp\u00e4rist\u00f6tieteiden laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Biological and Environmental Science", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Ekologia ja evoluutiobiologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Ecology and evolutionary biology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.date.updated", "value": "2014-12-07T14:23:42Z", "language": null, "element": "date", "qualifier": "updated", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": null, "element": 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"qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "t\u00e4pl\u00e4siilik\u00e4s", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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