| fullrecord |
[{"key": "dc.contributor.author", "value": "Hoikkala, Ville", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2014-11-11T09:33:48Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2014-11-11T09:33:48Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2014", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.other", "value": "oai:jykdok.linneanet.fi:1451177", "language": null, "element": "identifier", "qualifier": "other", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/44617", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4m\u00e4n tutkielman tavoitteena oli kehitt\u00e4\u00e4 graafisen k\u00e4ytt\u00f6liittym\u00e4n omaava monipuolinen\nsimulaatioymp\u00e4rist\u00f6, jolla voidaan mallintaa bakteerien levi\u00e4mist\u00e4 sairaalaymp\u00e4rist\u00f6ss\u00e4. Ohjelma\nmahdollistaa noin nelj\u00e4nkymmenen sairaalaparametrin asettamisen ja tulosten purkamisen\ntaulukkomuotoon. Kyseisess\u00e4 yksil\u00f6pohjaisessa mallissa keskityt\u00e4\u00e4n sairaalaty\u00f6ntekij\u00f6iden ja\npotilaiden v\u00e4lisiin vuorovaikutuksiin. Ty\u00f6ntekij\u00e4t toimivat vektoreina, levitt\u00e4en bakteeri-infektioita\npotilaiden v\u00e4lill\u00e4. Bakteerimallinnus yksitt\u00e4isen potilaan sis\u00e4ll\u00e4 on toteutettu matemaattisesti.\nBakteerit voivat kilpailla kesken\u00e4\u00e4n ja muuntua antibiooteille vastustuskykyisiksi; t\u00e4ll\u00f6in voidaan\nhy\u00f6dynt\u00e4\u00e4 faagiterapiaa, jossa infektioita hoidetaan bakteriofaageilla. Malli osoittaa, ett\u00e4 antibioottien\nja faagiterapian yht\u00e4aikainen k\u00e4ytt\u00f6 on huomattavasti tehokkaampaa kuin eriaikainen k\u00e4ytt\u00f6:\nyht\u00e4aikaisessa k\u00e4yt\u00f6ss\u00e4 sensitiivisten bakteereiden kokonaism\u00e4\u00e4r\u00e4 sairaalassa laski 29% ja\nantibioottiresistenttien bakteereiden m\u00e4\u00e4r\u00e4 10%. Sensitiivisyysanalyysissa selvisi, ett\u00e4 esimerkiksi\nhoitotodenn\u00e4k\u00f6isyysparametrilla on suuri, eksponentiaalinen vaikutus keskim\u00e4\u00e4r\u00e4iseen\nsairaalassaoloaikaan: 10% hoitotodenn\u00e4k\u00f6isyys johti 16 p\u00e4iv\u00e4n keskipituuteen, kun 100%\ntodenn\u00e4k\u00f6isyys johti 7 p\u00e4iv\u00e4n mittaiseen keskipituuteen. Ty\u00f6ntekij\u00f6iden hygieniak\u00e4yt\u00e4nn\u00f6t\nvaikuttavat vahvasti bakteerien kokonaism\u00e4\u00e4r\u00e4\u00e4n sairaalassa. T\u00e4ydet hygienatoimet eiv\u00e4t kuitenkaan\nriit\u00e4 koko sairaalan bakteerikannan tuhoamiseen, eiv\u00e4tk\u00e4 olemattomat hygienatoimet johda jokaisen\npotilaan infektioon. Tulosten merkityksellisyys on vahvasti riippuvaista parametrien arvoista, joista\nosa on laajalti spekulatiivisia. Mallia tulisi siis l\u00e4hinn\u00e4 k\u00e4ytt\u00e4\u00e4 riippuvaisuuksien etsimiseen ja\nherkkyyksien arvioimiseen. Ty\u00f6 tarjoaa pohjan vektoriv\u00e4litteisten ja yksil\u00f6pohjaisten\nsimulaatiomallien kehitt\u00e4miseen tulevaisuudessa.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "The objective of this project was to develop a simulation environment with a graphical user interface\nfor the study of nosocomial infections. The software allows for the tuning of nearly 40 different\nhospital parameters and for the export of results in spreadsheet form. The individual-based model\nfocuses on interactions between health-care workers and patients. Pathogens are spread between\npatients by the workers and the ensuing infections are modeled mathematically. Pathogen mutation to\nantibiotic-resistant strains is possible and the pathogens may outcompete one another. Phage therapy,\nthe utilization of bacteriophages in treating infections, is included alongside antibiotics as a treatment\noption. The model indicates that simultaneous use of phage therapy and antibiotics has clear\nadvantage to exclusive use: when simultaneous use is allowed the prevalence of susceptible bacteria\ndecreases by 29% and that of antibiotic resistant bacteria by 10% on the hospital population level. A\nsensitivity analysis reveals that treatment probability, a parameter describing the likelihood of an\ninfection being noticed, is highly influential in determining average duration of stay: 10% treatment\nprobability results in average duration of stay of 16 days, whereas 100% certainty results in average\nduration of stay of 7 days. The values in-between follow exponential law. Hand-washing compliance\nis observed to be strongly and reversely correlated with the prevalence of pathogens. However, full\ncompliance does not entirely eradicate the bacteria, nor does zero-compliance result in total saturation\nof the population. These limits are due to constant in- and outflux of patients, some incoming patients\nbeing colonized prior to arrival. Full saturation of the patient population does not occur when the rate\nof transfer is low enough to allow patients to leave the hospital before becoming infected.\nSignificance of the results is highly dependent on parameter values, which are often very speculative.\nThe model should therefore be primarily used to study dependencies and sensitivities of parameters.\nThe work lays foundation for the development of more general vector-mediated simulation engines in\nthe future.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Ville Hoikkala (vihoikka) on 2014-11-11 09:33:47.607463. Form: Pro gradu -lomake (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/pro-gradu-lomake). JyX data: [jyx_publishing-allowed (fi) =True]", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija@noreply.fi) on 2014-11-11T09:33:48Z\nNo. of bitstreams: 2\nURN:NBN:fi:jyu-201411113219.pdf: 1896065 bytes, checksum: e80f01d520f85a4997a0d19772bf72b4 (MD5)\nlicense.html: 4859 bytes, checksum: 391beca3ae0bfeaafc69766cc4f8f21c (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2014-11-11T09:33:48Z (GMT). No. of bitstreams: 2\nURN:NBN:fi:jyu-201411113219.pdf: 1896065 bytes, checksum: e80f01d520f85a4997a0d19772bf72b4 (MD5)\nlicense.html: 4859 bytes, checksum: 391beca3ae0bfeaafc69766cc4f8f21c (MD5)\n Previous issue date: 2014", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "1 verkkoaineisto (43 s.)", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "antibioottiresistenssi", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "faagiterapia", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Probing the interplay of microbes and medicine in a hospital setting using an individual-based model", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201411113219", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Bio- ja ymp\u00e4rist\u00f6tieteiden laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Biological and Environmental Science", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Solu- ja molekyylibiologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Cell and molecular biology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.date.updated", "value": "2014-11-11T09:33:49Z", "language": null, "element": "date", "qualifier": "updated", "schema": "dc"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": "fi", "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4013", "language": null, "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "simulointi", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "bakteerit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "sairaalat", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "antibioottiresistenssi", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "fagiterapia", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
|