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[{"key": "dc.contributor.author", "value": "Pellinen, Eeva-Kaarina", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2013-10-07T16:49:27Z", "language": "", "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2013-10-07T16:49:27Z", "language": "", "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2013", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.other", "value": "oai:jykdok.linneanet.fi:1284229", "language": null, "element": "identifier", "qualifier": "other", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/42301", "language": "", "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "TIIVISTELM\u00c4\r\n\u00c4\u00e4niymp\u00e4rist\u00f6n muutosten havaitseminen on t\u00e4rke\u00e4\u00e4 selviytymiselle. Aivojen her\u00e4tevasteista niin sanotun poikkeavuusnegatiivisuusvasteen (mismatch negativity, MMN) on ajateltu heijastavan t\u00e4llaisten muutosten tarkkaavuudesta riippumatonta havaitsemista. Tutkimustilanteissa poikkeavuusnegatiivisuusvaste voidaan synnytt\u00e4\u00e4 sirottelemalla toistuvien \u201fstandardi\u00e4\u00e4nten\u201f joukkoon joltakin \u00e4rsykeominaisuudeltaan havaittavissa m\u00e4\u00e4rin poikkeavia harvinaisia \u201fdeviantti\u00e4\u00e4ni\u00e4\u201f (niin sanottu oddball-asetelma). Poikkeavuusnegatiivisuusvasteen tuottamista on yleisesti pidetty aivokuoren toimintona. Hippokampuksen sen sijaan on ajateltu vaikuttavan huomattavampien muutosten havaitsemiseen ja huomion k\u00e4\u00e4nt\u00e4miseen n\u00e4ihin muutoksiin sek\u00e4 t\u00e4h\u00e4n liittyv\u00e4\u00e4n P3a-vasteen syntyyn. Me mittasimme kuuloaivokuoren ja hippokampuksen paikallisia kentt\u00e4pontetiaaleja (local field potentials, LFPs) \u00e4\u00e4nen kestomuutoksiin uretaanilla nukutetuilla rotilla tutkiaksemme vaikuttaako my\u00f6s hippokampus automaattiseen muutoksen havaitsemiseen ja poikkeavuusvasteen syntyyn. Tutkiaksemme muutoksen suunnan vaikutusta poikkeavuusvasteeseen k\u00e4ytimme kahta \u00e4rsyketilannetta, joista toisessa deviantti\u00e4\u00e4net olivat standardi\u00e4\u00e4ni\u00e4 pidempi\u00e4 ja toisessa lyhempi\u00e4. Lis\u00e4ksi \u00e4rsykev\u00e4lien pituuden vaikutusta poikkeavuusvasteeseen tutkittiin kahdella \u00e4rsyketilanteella, joista toisessa \u00e4rsykev\u00e4li oli 200 ja toisessa 500 millisekuntia. Poikkeavuusvasteita havaittiin sek\u00e4 kuuloaivokuorella ett\u00e4 hippokampusessa aikav\u00e4lill\u00e4 25-149.5 millisekuntia muutoksen alusta. Kestopidennykset aiheuttivat voimakkaita poikkeavuusvasteita, mutta poikkeavuusvasteet puuttuivat l\u00e4hes kokonaan kestolyhennyksiin. Poikkeavuusvasteet olivat voimakkaampia \u00e4rsykev\u00e4lien ollessa 500 millisekuntia kuin niiden ollessa 200 millisekuntia. N\u00e4m\u00e4 tulokset viittaavat siihen ett\u00e4 hippokampus saattaa osallistua muutoksen havaitsemiseen ja poikkeavuusnegatiivisuusvasteen syntyyn. Lis\u00e4ksi tulokset kestomuutoksen suunnan sek\u00e4 \u00e4rsykev\u00e4lin vaikutuksesta poikkeavuusvasteeseen ovat yhten\u00e4isi\u00e4 ihmisilt\u00e4 mitattujen poikkeavuusnegatiivisuusvastetutkimusten tulosten kanssa. T\u00e4m\u00e4 tukee rottien k\u00e4ytt\u00f6\u00e4 mallinnettaessa sek\u00e4 normaaleihin ett\u00e4 h\u00e4iriintyneisiin aivotoimintoihin liittyvi\u00e4 kuulotiedon k\u00e4sittelyn prosesseja keskushermostossa.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "ABSTRACT\r\nDetection of changes in the auditory environment is important for survival. The mismatch negativity (MMN) of the event-related potentials (ERPs) reflects automatic change detection that occurs independently from attention. In experimental conditions, MMN can be elicited by rare \u201fdeviant sounds\u201f, differing discernibly from the frequently occurring \u201fstandard sounds\u201f in respect of any stimulus feature (so-called oddball condition). The generation of MMN has generally been viewed as a cortical process. The hippocampus, then again, has been thought to contribute to the detection of more salient changes, to the switching of attention to these changes and to the generation of P3a of ERPs related to the attention shift. We measured auditory cortical and hippocampal local field potentials (LFPs) to sound duration changes in urethane-anesthetized rats in an oddball condition to study whether also the hippocampus plays a role in automatic change detection and generation of MMN. As the direction of the duration deviance has been suggested to have bearing on mismatch response, we applied two conditions with duration increments as deviant sounds in one condition and duration decrements as deviant sounds in the other condition. Moreover, two conditions with different inter-stimulus intervals (ISIs of 200 and 500 ms) were applied to study how the length of the intervals between the stimuli affects mismatch response. Mismatch responses were observed both in the auditory cortex and hippocampus at 25-149.5 ms after change onset. Duration increments elicited strong mismatch responses, but mismatch responses to duration decrements were almost completely absent. Stronger mismatch responses were also elicited when ISI was 500 ms than when it was 200 ms. These results indicate that hippocampus might play a role in automatic auditory change detection and in the generation of MMN. Moreover, the findings of the effect of duration deviation direction and ISI on mismatch response are consistent with the findings of human MMN. This lends further support for the use of rats when modeling central auditory processes related to both healthy and disrupted brain functions.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Eeva Pellinen (eevipell) on 2013-10-07 16:49:26.122080. Form: Pro gradu -lomake (1 tekij\u00e4) (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/pro-gradu-lomake-1-tekijae). JyX data:", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija@noreply.fi) on 2013-10-07T16:49:27Z\r\nNo. of bitstreams: 2\r\nURN:NBN:fi:jyu-201310072429.pdf: 588514 bytes, checksum: 7375fd2ef0f2fe421e89a6b6ca4f23fd (MD5)\r\nlicense.html: 107 bytes, checksum: a7d86e598caa500b1b433bbb9dc8ef1c (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2013-10-07T16:49:27Z (GMT). No. of bitstreams: 2\r\nURN:NBN:fi:jyu-201310072429.pdf: 588514 bytes, checksum: 7375fd2ef0f2fe421e89a6b6ca4f23fd (MD5)\r\nlicense.html: 107 bytes, checksum: a7d86e598caa500b1b433bbb9dc8ef1c (MD5)\r\n Previous issue date: 2013", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "1 verkkoaineisto.", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.title", "value": "Mismatch responses to sound duration changes in the rat auditory cortex and hippocampus", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201310072429", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Yhteiskuntatieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Social Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Psykologian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Psychology", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psykologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psychology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.date.updated", "value": "2013-10-07T16:49:27Z", "language": "", "element": "date", "qualifier": "updated", "schema": "dc"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": "fi", "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "202", "language": null, "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "poikkeavuusnegatiivisuus", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "kuulo", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "hippokampus", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "\u00e4rsykkeet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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