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[{"key": "dc.contributor.author", "value": "Ylikulju, Teemu", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2013-09-26T11:40:20Z", "language": "", "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2013-09-26T11:40:20Z", "language": "", "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2013", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.other", "value": "oai:jykdok.linneanet.fi:1281143", "language": null, "element": "identifier", "qualifier": "other", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/42229", "language": "", "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Duchennen lihasdystrofia (DMD) on perinn\u00f6llinen sairaus, jonka esiintyvyys on noin 1/3600\r\npoikavauvasta. Siihen liittyy lihasten heikkoutta, rappeutumista ja kognitiivista vajavaisuutta. Taudin aiheuttaa mutatoitunut geeni dystrophiini proteiinille. On esitetty, ett\u00e4 kognitiivinen vajavaisuus johtuu taudin vaikutuksesta ehk\u00e4ist\u00e4 neurogeneesi\u00e4. Neurogeneesi on prosessi, joka jatkuvasti synnytt\u00e4\u00e4 uusia hermosoluja p\u00e4\u00e4asiallisesti subventikulaari alueella ja hippokampuksen dentate gyruksella. Hoitoa ja parannusta tautiin tutkitaan yleens\u00e4 mdx-hiirill\u00e4, joiden taudin etiologia on riitt\u00e4v\u00e4n l\u00e4hell\u00e4 ihmisten tautia. T\u00e4m\u00e4 tutkimus keskittyy pyrkimykseen vaikuttaa mdx-hiirten neurogeneesiin aerobisen liikunnan ja myostatiinin est\u00e4j\u00e4n v\u00e4lityksell\u00e4. Myostatiinin est\u00e4j\u00e4 lis\u00e4\u00e4 nis\u00e4kk\u00e4iden lihaskasvua. Tutkimuksella on kolme p\u00e4\u00e4fokusta: 1. Vaikuttaako aerobinen\r\nharjoittelu mdx-hiirten neurogeneesiin? 2. Vaikuttavatko kasvaneet lihakset mdx-hiirten\r\nneurogeneesiin? 3. Vaikuttavatko aerobinen liikunta ja kasvaneiden lihasten yhteisvaikutus mdx-hiirten neurogeneesiin? Lis\u00e4ksi myostatiinin est\u00e4j\u00e4n vaikutusta juoksemisvalmiuteen arvioitiin.\r\nMyostatiinin ehk\u00e4isy vaikutti juoksemiseen lyhent\u00e4m\u00e4ll\u00e4 juoksumatkoja kokeen alkupuolella.\r\nVastoin odotuksia lasketuista jakautuvista uusien hermosolujen lukum\u00e4\u00e4rist\u00e4 ei l\u00f6ytynyt\r\ntilastollisesti merkitsevi\u00e4 eroja ryhmien v\u00e4lill\u00e4. Liikunta, suuret lihakset tai niiden yhdistelm\u00e4 eiv\u00e4t t\u00e4m\u00e4n tutkimuksen mukaan ole riitt\u00e4vi\u00e4 tai tarpeeksi vaikuttavia tekij\u00f6it\u00e4 muuttamaan mdx-hiirten neurogeneesi\u00e4. Toinen mahdollinen syy erojen l\u00f6ytym\u00e4tt\u00f6myyteen solujen lukum\u00e4\u00e4rist\u00e4 voi olla, ett\u00e4 tauti ei ollut vaikuttanut mdx-hiirten neurogeneesiin.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Duchenne`s muscular dystrophy (DMD) is an inherited disorder that occurs with 1 out of every 3600 male infants. It involves muscular weakness, dystrophy and cognitive dysfunction. The disorder is caused by a defective gene for dystrophin protein. It has been hypothesized that cognitive deficit occurs because DMD downregulates patients\u00b4 neurogenesis. Neurogenesis is a process where new brain cells are continuously generated at subventicular zone and dentate gyrus of hippocampus. Cures for DMD are mainly researched with mdx mice. Etiology of the mdx is close enough to that of patients with DMD. This research focuses on an attempt to enhance the neurogenesis of mdx mice via aerobic exercise and myostatin inhibition. Myostatin inhibition enhances mammals\u2019 muscle growth. Research has three main focus: 1. Does aerobic exercise enhance neurogenesis in mdx mice? 2. Do bigger muscles enhance neurogenesis in mdx mice? 3. Does aerobic exercise with bigger muscles enhance neurogenesis in mdx mice? Also the effect of myostatin blocking on running readiness was examined.\r\nMyostatin inhibition affected running by decreasing running distances compared to pbs treated runners at the beginning of the experience. Against expectations there where no significant differences in proliferating new born cell count between any of the groups. It seems to be that neither exercise nor bigger muscles or their combination are factors that are sufficient or efficient enough to affect the neurogenesis of mdx mice. The other reasons for not finding any differences between cell counts could be that the neurogenesis of the mdx mice was not affected by the disease.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Teemu Ylikulju (tejuylik) on 2013-09-26 11:40:20.328069. Form: Pro gradu -lomake (1 tekij\u00e4) (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/pro-gradu-lomake-1-tekijae). JyX data:", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija@noreply.fi) on 2013-09-26T11:40:20Z\r\nNo. of bitstreams: 2\r\nURN:NBN:fi:jyu-201309262361.pdf: 792507 bytes, checksum: 532f469c3deea4242e2909cf6af963d0 (MD5)\r\nlicense.html: 107 bytes, checksum: a7d86e598caa500b1b433bbb9dc8ef1c (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2013-09-26T11:40:20Z (GMT). No. of bitstreams: 2\r\nURN:NBN:fi:jyu-201309262361.pdf: 792507 bytes, checksum: 532f469c3deea4242e2909cf6af963d0 (MD5)\r\nlicense.html: 107 bytes, checksum: a7d86e598caa500b1b433bbb9dc8ef1c (MD5)\r\n Previous issue date: 2013", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "27 sivua", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "myostatiini", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "neurogeneesi", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "Neurogenesis", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "Duchenne muscular dystrophy", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "mdx mice", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "aerobic exercise", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "myostatin blocker", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "nitric oxide", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "An attempt to enhance neurogenesis of mdx mice via aerobic exercise and myostatin inhibition", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201309262361", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Yhteiskuntatieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Social Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Psykologian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Psychology", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psykologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psychology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.date.updated", "value": "2013-09-26T11:40:21Z", "language": "", "element": "date", "qualifier": "updated", "schema": "dc"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": "fi", "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "202", "language": null, "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "Duchennen lihasdystrofia", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "aerobinen harjoittelu", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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