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[{"key": "dc.contributor.author", "value": "Eronen, Antti", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Lagerstedt, Elina", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2013-09-26T10:44:34Z", "language": "", "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2013-09-26T10:44:34Z", "language": "", "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2013", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.other", "value": "oai:jykdok.linneanet.fi:1290470", "language": null, "element": "identifier", "qualifier": "other", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/42224", "language": "", "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "TAUSTA: Vaikka geenien ja ymp\u00e4rist\u00f6n toisistaan riippumaton vaikutus skitsofrenian etiologiaan on osoitettu, ei aiemmissa tutkimuksissa ole kiinnitetty huomiota n\u00e4iden yhdysvaikutuksiin. Suomalaisessa skitsofrenian adoptiolapsitutkimuksessa geeni-ymp\u00e4rist\u00f6 yhdysvaikutuksen on havaittu olevan yhteydess\u00e4 yleisesti adoptiolasten psykiatrisiin h\u00e4iri\u00f6ihin.\r\nTUTKIMUSONGELMA: Ennustimme adoptiolasten seurannassa todettuja mielenterveyden h\u00e4iri\u00f6it\u00e4 perustuen heid\u00e4n adoptiovanhempiensa yksil\u00f6-Rorschach -testiss\u00e4 todettuihin kommunikaatioh\u00e4iri\u00f6ihin standardisoituna puheen pituudella. Vertasimme t\u00e4t\u00e4 menetelm\u00e4\u00e4n, jossa kommunikaatioh\u00e4iri\u00f6t oli standardisoitu transaktioiden (vastausten) lukum\u00e4\u00e4r\u00e4ll\u00e4 l\u00f6yt\u00e4\u00e4ksemme mahdollisia eroja tuloksissa n\u00e4iden kahden metodin v\u00e4lill\u00e4.\r\nMENETELM\u00c4: Adoptiolapset (n=108), joilla ei ollut DSM-III-R diagnoosia alkumittauksissa, jaettiin geneettisen riskin perusteella korkean- ja matalan riskin ryhmiin perustuen heid\u00e4n biologisen \u00e4itins\u00e4 skitsofrenian spektriryhm\u00e4n h\u00e4iri\u00f6n diagnoosiin. Ymp\u00e4rist\u00f6riskimuuttujana k\u00e4ytimme t\u00e4ss\u00e4 tutkimuksessa vanhempien kommunikaatioh\u00e4iri\u00f6t\u00e4 (Communication Deviance, CD). Adoptiolapsen perinn\u00f6llisell\u00e4 riskill\u00e4 ja adoptiovanhempien kommunikaatioh\u00e4iri\u00f6ill\u00e4 sek\u00e4 n\u00e4iden yhdysvaikutuksella ennustettiin keskim\u00e4\u00e4rin 12.5 vuoden seurannan j\u00e4lkeen adoptiolasten mielenterveyden h\u00e4iri\u00f6it\u00e4. TULOKSET: Lapsen perinn\u00f6llisen riskin sek\u00e4 vanhemman kommunikaatioh\u00e4iri\u00f6ihin kuuluvan osa-asteikon \u201dajattelun h\u00e4iri\u00f6t ja ristiriitaisuudet\u201d yhdysvaikutuksella todettiin olevan yhteys adoptiolasten mielenterveyden h\u00e4iri\u00f6ihin. Ainoastaan perinn\u00f6llisell\u00e4 riskill\u00e4 sairastua skitsofreniaspektrin ryhm\u00e4n h\u00e4iri\u00f6\u00f6n todettiin olevan yhteys adoptiolapsen mielenterveyden h\u00e4iri\u00f6ihin, kun selitysmallissa olivat mukana perinn\u00f6llinen riski, adoptiovanhempien kaikki kommunikaatioh\u00e4iri\u00f6t ja n\u00e4iden yhdysvaikutus.\r\nJOHTOP\u00c4\u00c4T\u00d6S: K\u00e4ytt\u00e4m\u00e4mme menetelm\u00e4, jossa vanhempien kommunikaatioh\u00e4iri\u00f6pisteet jaettiin heid\u00e4n testiosassa puhumiensa sanojen m\u00e4\u00e4r\u00e4ll\u00e4, ei osoittanut genetiikka-ymp\u00e4rist\u00f6yhdysvaikutusta lasten psykiatristen h\u00e4iri\u00f6iden selitt\u00e4j\u00e4n\u00e4 lukuun ottamatta viidett\u00e4 CD-alaryhm\u00e4\u00e4 (ajattelun h\u00e4iri\u00f6t ja ristiriitaisuudet). Vertailukohtana k\u00e4ytt\u00e4m\u00e4mme menetelm\u00e4, jossa kommunikaatioh\u00e4iri\u00f6pisteet oli jaettu transaktioiden m\u00e4\u00e4r\u00e4ll\u00e4, osoitti vahvan ymp\u00e4rist\u00f6-genetiikka yhdysvaikutuksen, vaikka geneettiset- ja ymp\u00e4rist\u00f6riskitekij\u00e4t eiv\u00e4t yksin\u00e4\u00e4n osoittautuneet merkitt\u00e4viksi. N\u00e4in ollen geneettinen p\u00e4\u00e4vaikutus ylikorostuu, mik\u00e4li kommunikaatioh\u00e4iri\u00f6pisteit\u00e4 standardisoidaan puheen pituudella.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "BACKGROUND: Although the main effects of genes and the environment have been independently explored in the etiology of schizophrenia, previous research has not paid much attention to possible interactions between these two. In the Finnish Adoptive Family Study of Schizophrenia, gene-environment interactions have been found to be the defining predictive factor for the outbreak of general adoptee mental health problems.\r\nAIMS: We predicted the outbreak of general mental health disorders in adoptees at the follow-up by their parents\u2019 Communication Deviance (CD) scores standardized by the length-of-speech in the individual Rorschach tests. We also did comparisons between these and Communication Deviance scores standardized by the number of transactions to find out whether these two standardization methods would yield different results.\r\nMETHOD: Adoptees (n = 108) with no DSM-III diagnoses at initial assessment were divided into genetic high-risk and low-risk groups based on their biological mothers\u2019 schizophrenia-spectrum diagnoses. We then calculated the Communication Deviance scores for the rearing family adoptive parents by dividing their individual CD scores by the number of words spoken during the individual Rorschach test. We predicted general mental health disorders of the adoptees after a 12.5 year follow-up using the high genetic risk and the adoptive parents Communication Deviance and their interaction.\r\nRESULTS: We found the interaction between the high genetic risk of the adoptee and high scores on the CD subscale \u201cParental reasoning problems and contradictions\u201d to be predictors of general psychiatric disorders in the adoptee. The main effect of high genetic risk was found to be the only significant predictor of mental disorders in the adoptees when the total CD scores of the adoptive parents and their interaction with the high genetic risk were included in the model.\r\nCONCLUSION: Communication Deviance scores of the adoptive parents standardized by dividing them with the number of words spoken do not show any gene-environment interactions affecting the outbreak of general mental health disorders in the adoptees (except for CD subgroup 5, Reasoning Problems and Contradictions). However, earlier research has verified that total Communication Deviance scores standardized by the number of individual Rorschach test transactions do show a very strong gene-environment interaction, whereas the main effects of genes and the environment become non-significant. The genetic main effects therefore appear to become over-highlighted whenever the length-of-speech standardization method is used.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Antti Eronen (anmaeron) on 2013-09-26 10:44:33.649993. Form: Pro gradu -lomake (2 tekij\u00e4\u00e4) (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/pro-gradu-lomake-2-tekijaa). JyX data:", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija@noreply.fi) on 2013-09-26T10:44:34Z\r\nNo. of bitstreams: 2\r\nURN:NBN:fi:jyu-201309262360.pdf: 301320 bytes, checksum: 19360580c5ff1070fb8050da83f393c5 (MD5)\r\nlicense.html: 5569 bytes, checksum: 8b27ea0329505f5326b6917a2e3cd9de (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2013-09-26T10:44:34Z (GMT). No. of bitstreams: 2\r\nURN:NBN:fi:jyu-201309262360.pdf: 301320 bytes, checksum: 19360580c5ff1070fb8050da83f393c5 (MD5)\r\nlicense.html: 5569 bytes, checksum: 8b27ea0329505f5326b6917a2e3cd9de (MD5)\r\n Previous issue date: 2013", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "1 verkkoaineisto (20 sivua)", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "communication deviance", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "schizophrenia", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "gene environment interaction", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "adoption study", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Prediction of adoptee psychiatric disorders by interaction of genetic risk of schizophrenia and communication deviance divided by the word count of adoptive parents", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201309262360", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", 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