Computational modeling of protein diffusion in the cell nucleus using the lattice-Boltzmann method

The number of fluorescence applications and methods of analysis is growing in the biological and related sciences. The aim of this work was to accurately determine the diffusion coefficient in nucleus, diffusion in the cytoplasm and nucleo-cytoplasmic translocation should be considered as well. Fluo...

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Bibliografiset tiedot
Päätekijä: Filippovych, Kateryna
Muut tekijät: Matemaattis-luonnontieteellinen tiedekunta, Faculty of Sciences, Fysiikan laitos, Department of Physics, University of Jyväskylä, Jyväskylän yliopisto
Aineistotyyppi: Pro gradu
Kieli:eng
Julkaistu: 2012
Aiheet:
Linkit: https://jyx.jyu.fi/handle/123456789/40089
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author Filippovych, Kateryna
author2 Matemaattis-luonnontieteellinen tiedekunta Faculty of Sciences Fysiikan laitos Department of Physics University of Jyväskylä Jyväskylän yliopisto
author_facet Filippovych, Kateryna Matemaattis-luonnontieteellinen tiedekunta Faculty of Sciences Fysiikan laitos Department of Physics University of Jyväskylä Jyväskylän yliopisto Filippovych, Kateryna Matemaattis-luonnontieteellinen tiedekunta Faculty of Sciences Fysiikan laitos Department of Physics University of Jyväskylä Jyväskylän yliopisto
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description The number of fluorescence applications and methods of analysis is growing in the biological and related sciences. The aim of this work was to accurately determine the diffusion coefficient in nucleus, diffusion in the cytoplasm and nucleo-cytoplasmic translocation should be considered as well. Fluorescence recovery after photobleaching (FRAP) experiments were used in order to study protein diffusion. A numerical model for FRAP was used to determine the diffusion properties of proteins. The present method removed the difficulties of the conventional analysis, could produce, interesting results for protein diffusion in the cell.
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spellingShingle Filippovych, Kateryna Computational modeling of protein diffusion in the cell nucleus using the lattice-Boltzmann method Nucleus diffusion FRAP. Fysiikka Physics 4021 fluoresenssi diffuusio proteiinit
title Computational modeling of protein diffusion in the cell nucleus using the lattice-Boltzmann method
title_full Computational modeling of protein diffusion in the cell nucleus using the lattice-Boltzmann method
title_fullStr Computational modeling of protein diffusion in the cell nucleus using the lattice-Boltzmann method Computational modeling of protein diffusion in the cell nucleus using the lattice-Boltzmann method
title_full_unstemmed Computational modeling of protein diffusion in the cell nucleus using the lattice-Boltzmann method Computational modeling of protein diffusion in the cell nucleus using the lattice-Boltzmann method
title_short Computational modeling of protein diffusion in the cell nucleus using the lattice-Boltzmann method
title_sort computational modeling of protein diffusion in the cell nucleus using the lattice boltzmann method
title_txtP Computational modeling of protein diffusion in the cell nucleus using the lattice-Boltzmann method
topic Nucleus diffusion FRAP. Fysiikka Physics 4021 fluoresenssi diffuusio proteiinit
topic_facet 4021 FRAP. Fysiikka Nucleus Physics diffusion diffuusio fluoresenssi proteiinit
url https://jyx.jyu.fi/handle/123456789/40089 http://www.urn.fi/URN:NBN:fi:jyu-201210252786
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