Production of 15O for medical applications

This thesis examines and compares nuclear reactions suitable for the production of the oxygen-15 isotope. Oxygen-15 is widely utilized in medical applications, but its short half-life (t₁/₂ = 122.24 s) requires on-site production in hospitals or nearby facilities. While its rapid decay presents lo...

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Bibliografiset tiedot
Päätekijä: Seppälä, Anni
Muut tekijät: Matemaattis-luonnontieteellinen tiedekunta, Faculty of Sciences, Fysiikan laitos, Department of Physics, Jyväskylän yliopisto, University of Jyväskylä
Aineistotyyppi: Pro gradu
Kieli:eng
Julkaistu: 2025
Aiheet:
Linkit: https://jyx.jyu.fi/handle/123456789/103302
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author Seppälä, Anni
author2 Matemaattis-luonnontieteellinen tiedekunta Faculty of Sciences Fysiikan laitos Department of Physics Jyväskylän yliopisto University of Jyväskylä
author_facet Seppälä, Anni Matemaattis-luonnontieteellinen tiedekunta Faculty of Sciences Fysiikan laitos Department of Physics Jyväskylän yliopisto University of Jyväskylä Seppälä, Anni Matemaattis-luonnontieteellinen tiedekunta Faculty of Sciences Fysiikan laitos Department of Physics Jyväskylän yliopisto University of Jyväskylä
author_sort Seppälä, Anni
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description This thesis examines and compares nuclear reactions suitable for the production of the oxygen-15 isotope. Oxygen-15 is widely utilized in medical applications, but its short half-life (t₁/₂ = 122.24 s) requires on-site production in hospitals or nearby facilities. While its rapid decay presents logistical challenges, the isotope’s favorable properties for PET imaging make its production highly relevant. This study explores alternative reaction pathways to improve its availability and clinical applicability. The analysis focused on the cross sections of selected nuclear reactions as a function of projectile energy. Experimental datasets from the EXFOR database were compared to theoretical cross section values calculated using TALYS simulations. Graphs were generated to evaluate the behavior and feasibility of each reaction. The results indicate that the ¹⁴N(d,n)¹⁵O reaction remains the most efficient pathway for ¹⁵O production, achieving high cross sections at low energy levels. The ¹⁵N(p,n)¹⁵O reaction also showed considerable promise, with the highest cross-section values observed in the study, but concerns remain regarding the availability and cost of enriched ¹⁵N target material. The ¹⁶O(p,pn)¹⁵O reaction demonstrated potential, benefiting from the abundance of ¹⁶O in water, although its complex reaction mechanism and the required proton accelerator scale may pose challenges for efficient production. On the other hand, despite having the lowest peak cross section among the studied reactions, the ¹⁶O(γ,n)¹⁵O pathway remains a promising candidate due to the natural abundance of ¹⁶O and the potential for gamma-induced production without the need for large-scale particle accelerators. However, practical implementation will depend on advances in high-flux gamma-ray sources or the development of new generation technologies.
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Oxygen-15 is widely utilized in medical applications, but its short half-life (t\u2081/\u2082 = 122.24 s) requires on-site production in hospitals or nearby facilities. While its rapid decay presents logistical challenges, the isotope\u2019s favorable properties for PET imaging make its production highly relevant. This study explores alternative reaction pathways to improve its availability and clinical applicability.\n\nThe analysis focused on the cross sections of selected nuclear reactions as a function of projectile energy. Experimental datasets from the EXFOR database were compared to theoretical cross section values calculated using TALYS simulations. Graphs were generated to evaluate the behavior and feasibility of each reaction.\n\nThe results indicate that the \u00b9\u2074N(d,n)\u00b9\u2075O reaction remains the most efficient pathway for \u00b9\u2075O production, achieving high cross sections at low energy levels. The \u00b9\u2075N(p,n)\u00b9\u2075O reaction also showed considerable promise, with the highest cross-section values observed in the study, but concerns remain regarding the availability and cost of enriched \u00b9\u2075N target material.\n\nThe \u00b9\u2076O(p,pn)\u00b9\u2075O reaction demonstrated potential, benefiting from the abundance of \u00b9\u2076O in water, although its complex reaction mechanism and the required proton accelerator scale may pose challenges for efficient production. On the other hand, despite having the lowest peak cross section among the studied reactions, the \u00b9\u2076O(\u03b3,n)\u00b9\u2075O pathway remains a promising candidate due to the natural abundance of \u00b9\u2076O and the potential for gamma-induced production without the need for large-scale particle accelerators. 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spellingShingle Seppälä, Anni Production of 15O for medical applications oxygen-15 isotope production reactions cross section TALYS Fysiikka Physics isotoopit ydinfysiikka ydinreaktiot
title Production of 15O for medical applications
title_full Production of 15O for medical applications
title_fullStr Production of 15O for medical applications Production of 15O for medical applications
title_full_unstemmed Production of 15O for medical applications Production of 15O for medical applications
title_short Production of 15O for medical applications
title_sort production of 15o for medical applications
title_txtP Production of 15O for medical applications
topic oxygen-15 isotope production reactions cross section TALYS Fysiikka Physics isotoopit ydinfysiikka ydinreaktiot
topic_facet Fysiikka Physics TALYS cross section isotoopit isotope production reactions oxygen-15 ydinfysiikka ydinreaktiot
url https://jyx.jyu.fi/handle/123456789/103302 http://www.urn.fi/URN:NBN:fi:jyu-202506105103
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