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[{"key": "dc.contributor.advisor", "value": "Pihko, Petri", "language": null, "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Mondal, Pradip", "language": null, "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Suni, Eevi", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2025-06-10T06:27:11Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2025-06-10T06:27:11Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2025", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/103299", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4m\u00e4n Pro Gradu -tutkielman kirjallinen osa k\u00e4sittelee isoprenoidien biosynteesi\u00e4 sek\u00e4 prenyloitujen aromaattisten luonnonainerakenteiden potentiaalia l\u00e4\u00e4keainekemiassa. Kokeellinen osa k\u00e4sittelee asperspiropeenin totaalisynteesi\u00e4 sek\u00e4 synteesisuunnitelman testaamista.\nPrenyloidut aromaattiset yhdisteet muodostavat laajan joukon luonnonaineita, joilla on biologista aktiivisuutta muun muassa sy\u00f6p\u00e4solulinjoja vastaan sek\u00e4 antibioottisia ominaisuuksia. Luonnonainerakenteiden muuntaminen l\u00e4\u00e4keaineiksi ei kuitenkaan ole yksinkertaista ja ongelmatonta. Luonnonaineiden biosynteesit tapahtuvat tyypillisesti spesifeiss\u00e4 olosuhteissa entsyymien katalysoimana, jonka vuoksi niiden toistaminen laboratorio-olosuhteessa voi olla haastavaa tai taloudellisesti kannattamatonta.\nVaikka luonnonaineiden muuntaminen l\u00e4\u00e4keaineiksi on haastavaa, se ei ole mahdotonta ja monen laajalti k\u00e4ytetyn l\u00e4\u00e4keaineen rakenne on alun perin eristetty luonnosta. Luonnossa tapahtuva prenylointireaktio sek\u00e4 isoprenoidiketjujen jatkoreaktiot ovat prenyylitransferaasientsyymien katalysoimia reaktioita. Kirjallisen osan lopussa on esitetty onnistuneita biomimeettisia synteesej\u00e4 prenyloiduille luonnonainerakenteille sek\u00e4 k\u00e4sitelty biomimeettisen synteesin tarjoamia mahdollisuuksia sek\u00e4 haasteita.\nKokeellisessa osassa pyrittiin testaamaan Asperspiropeenille tehdyn totaalisynteesisuunnitelman nelj\u00e4\u00e4 ensimm\u00e4ist\u00e4 vaihetta. Synteesisuunnitelman kolmas vaihe, epoksidointi ei kuitenkaan tuottanut haluttua rakennetta, joten nelj\u00e4nnen vaiheen dihydroksylointia ei p\u00e4\u00e4sty testaamaan. Lopulta kokeellinen osa koostui p\u00e4\u00e4osin alkyloinnin optimoinnista sek\u00e4 vaihtoehtoisten epoksidointireaktioiden testaamisesta. Kokeellisen osan totaalisynteesisuunnitelman testaamisessa esiintyi monia haasteita, joiden syit\u00e4 ja vaihtoehtoisia synteesireittej\u00e4 on pohdittu kokeellisen osan yhteenvedossa.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2025-06-10T06:27:11Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2025-06-10T06:27:11Z (GMT). No. of bitstreams: 0\n Previous issue date: 2025", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "97", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": null, "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "biomimeettinen synteesi", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Elektronirikkaiden aromaattien prenylointi : asperspiropeenin totaalisynteesi", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202506105100", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Kemian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Chemistry", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": null, "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": null, "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Orgaaninen kemia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Organic Chemistry", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.copyright", "value": "\u00a9 The Author(s)", "language": "fi", "element": "rights", "qualifier": "copyright", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.yso", "value": "luonnonaineet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "synteesi", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "terpeenit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "kemia", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "orgaaninen kemia", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.description.accessibilityfeature", "value": "unknown accessibility", "language": "en", "element": "description", "qualifier": "accessibilityfeature", "schema": "dc"}, {"key": "dc.description.accessibilityfeature", "value": "ei tietoa saavutettavuudesta", "language": "fi", "element": "description", "qualifier": "accessibilityfeature", "schema": "dc"}]
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