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[{"key": "dc.contributor.advisor", "value": "Nissinen, Maija", "language": null, "element": "contributor", "schema": "dc", "qualifier": "advisor"}, {"key": "dc.contributor.author", "value": "Piipponen, Anni", "language": null, "element": "contributor", "schema": "dc", "qualifier": "author"}, {"key": "dc.date.accessioned", "value": "2025-04-24T06:43:46Z", "language": null, "element": "date", "schema": "dc", "qualifier": "accessioned"}, {"key": "dc.date.available", "value": "2025-04-24T06:43:46Z", "language": null, "element": "date", "schema": "dc", "qualifier": "available"}, {"key": "dc.date.issued", "value": "2025", "language": null, "element": "date", "schema": "dc", "qualifier": "issued"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/101607", "language": null, "element": "identifier", "schema": "dc", "qualifier": "uri"}, {"key": "dc.description.abstract", "value": "T\u00e4ss\u00e4 kandidaatintutkielmassa tarkastellaan syklodekstriinin ja sen johdannaisten roolia l\u00e4\u00e4keainekuljettimena erityisesti sy\u00f6p\u00e4l\u00e4\u00e4kkeiden kohdalla. Tutkielma keskittyy syklodekstriinien kykyyn muodostaa inkluusio- eli is\u00e4nt\u00e4-vieras-komplekseja l\u00e4\u00e4keaineiden kanssa. T\u00e4m\u00e4 kapselointiprosessi parantaa l\u00e4\u00e4keaineiden liukoisuutta, biologista hy\u00f6tyosuutta ja kohdennettavuutta, mik\u00e4 tekee syklodekstriineist\u00e4 houkuttelevia l\u00e4\u00e4keainekuljettimia.\n\nTutkielmassa keskityt\u00e4\u00e4n erityisesti \u03b2-syklodekstriiniin ja sen johdannaisiin, kuten hydroksipropyyli-\u03b2-syklodekstriiniin (HP-\u03b2-CD), sulfobutyylieetteri-\u03b2-syklodekstriiniin (SBE-\u03b2-CD) ja metyloituihin syklodekstriineihin (M-\u03b2-CD). N\u00e4iden johdannaisten kemiallisia ominaisuuksia ja vaikutusta l\u00e4\u00e4keaineiden vapautumiseen analysoidaan kirjallisuuden perusteella. Syklodekstriinijohdannaisia hy\u00f6dynnet\u00e4\u00e4n kuljetinaineiden lis\u00e4ksi nanoteknologisissa l\u00e4\u00e4keannosteluj\u00e4rjestelmiss\u00e4, jotka mahdollistavat tarkemman kohdentamisen ja hallitun l\u00e4\u00e4kkeen vapautumisen elimist\u00f6ss\u00e4.\n\nTutkimustulokset osoittavat, ett\u00e4 syklodekstriinijohdannaiset voivat parantaa sy\u00f6p\u00e4l\u00e4\u00e4kkeiden tehokkuutta v\u00e4hent\u00e4m\u00e4ll\u00e4 niiden toksisuutta ja tehostamalla kohdentumista sy\u00f6p\u00e4soluihin. Syklodekstriinit mahdollistavat perinteisten kemoterapeuttisten aineiden sek\u00e4 uudelleenkohdennettujen l\u00e4\u00e4kkeiden hy\u00f6dynt\u00e4misen sy\u00f6v\u00e4n hoidossa. Esimerkiksi monet kapseloitavat l\u00e4\u00e4keaineet, kuten disulfiraami, ovat osoittaneet hy\u00f6tyv\u00e4ns\u00e4 syklodekstriineihin perustuvista kuljetusj\u00e4rjestelmist\u00e4.\n\nVaikka syklodekstriinien k\u00e4ytt\u00f6 l\u00e4\u00e4kekuljettimina on lupaavaa, niiden pitk\u00e4aikaisvaikutuksista ja optimaalisista modifikaatioista tarvitaan viel\u00e4 lis\u00e4\u00e4 tutkimusta. Erityisesti syklodekstriinien yhdist\u00e4minen muihin nanoteknologisiin l\u00e4hestymistapoihin voi tarjota entist\u00e4 tehokkaampia ratkaisuja sy\u00f6v\u00e4n hoitoon ja edist\u00e4\u00e4 tulevaisuudessa kohdennettujen l\u00e4\u00e4keannosteluj\u00e4rjestelmien kehityst\u00e4.", "language": "fi", "element": "description", "schema": "dc", "qualifier": "abstract"}, {"key": "dc.description.abstract", "value": "", "language": "en", "element": "description", "schema": "dc", "qualifier": "abstract"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2025-04-24T06:43:46Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "schema": "dc", "qualifier": "provenance"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2025-04-24T06:43:46Z (GMT). No. of bitstreams: 0\n Previous issue date: 2025", "language": "en", "element": "description", "schema": "dc", "qualifier": "provenance"}, {"key": "dc.format.extent", "value": "28", "language": null, "element": "format", "schema": "dc", "qualifier": "extent"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "schema": "dc", "qualifier": "iso"}, {"key": "dc.rights", "value": "In Copyright", "language": null, "element": "rights", "schema": "dc", "qualifier": null}, {"key": "dc.subject.other", "value": "l\u00e4\u00e4keainekuljetin", "language": null, "element": "subject", "schema": "dc", "qualifier": "other"}, {"key": "dc.subject.other", "value": "inkluusio-kompleksi", "language": null, "element": "subject", "schema": "dc", "qualifier": "other"}, {"key": "dc.subject.other", "value": "sy\u00f6p\u00e4l\u00e4\u00e4keaine", "language": null, "element": "subject", "schema": "dc", "qualifier": "other"}, {"key": "dc.title", "value": "Syklodekstriinijohdannaiset sy\u00f6p\u00e4l\u00e4\u00e4keaineiden kuljetuksessa", "language": null, "element": "title", "schema": "dc", "qualifier": null}, {"key": "dc.type", "value": "bachelor thesis", "language": null, "element": "type", "schema": "dc", "qualifier": null}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202504243427", "language": null, "element": "identifier", "schema": "dc", "qualifier": "urn"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "schema": "dc", "qualifier": "faculty"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "schema": "dc", "qualifier": "faculty"}, {"key": "dc.contributor.department", "value": "Kemian laitos", "language": "fi", "element": "contributor", "schema": "dc", "qualifier": "department"}, {"key": "dc.contributor.department", "value": "Department of Chemistry", "language": "en", "element": "contributor", "schema": "dc", "qualifier": "department"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": null, "element": "contributor", "schema": "dc", "qualifier": "organization"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": null, "element": "contributor", "schema": "dc", "qualifier": "organization"}, {"key": "dc.subject.discipline", "value": "Orgaaninen kemia", "language": "fi", "element": "subject", "schema": "dc", "qualifier": "discipline"}, {"key": "dc.subject.discipline", "value": "Organic Chemistry", "language": "en", "element": "subject", "schema": "dc", "qualifier": "discipline"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_7a1f", "language": null, "element": "type", "schema": "dc", "qualifier": "coar"}, {"key": "dc.rights.copyright", "value": "\u00a9 The Author(s)", "language": "fi", "element": "rights", "schema": "dc", "qualifier": "copyright"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "schema": "dc", "qualifier": "accesslevel"}, {"key": "dc.type.publication", "value": "bachelorThesis", "language": null, "element": "type", "schema": "dc", "qualifier": "publication"}, {"key": "dc.subject.yso", "value": "l\u00e4\u00e4keaineet", "language": null, "element": "subject", "schema": "dc", "qualifier": "yso"}, {"key": "dc.subject.yso", "value": "sy\u00f6p\u00e4taudit", "language": null, "element": "subject", "schema": "dc", "qualifier": "yso"}, {"key": "dc.subject.yso", "value": "l\u00e4\u00e4kkeet", "language": null, "element": "subject", "schema": "dc", "qualifier": "yso"}, {"key": "dc.subject.yso", "value": "kemia", "language": null, "element": "subject", "schema": "dc", "qualifier": "yso"}, {"key": "dc.subject.yso", "value": "syklodekstriinit", "language": null, "element": "subject", "schema": "dc", "qualifier": "yso"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "schema": "dc", "qualifier": "url"}, {"key": "dc.description.accessibilityfeature", "value": "unknown accessibility", "language": "en", "element": "description", "schema": "dc", "qualifier": "accessibilityfeature"}, {"key": "dc.description.accessibilityfeature", "value": "ei tietoa saavutettavuudesta", "language": "fi", "element": "description", "schema": "dc", "qualifier": "accessibilityfeature"}]
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