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[{"key": "dc.contributor.advisor", "value": "Nissinen, Maija", "language": null, "element": "contributor", "schema": "dc", "qualifier": "advisor"}, {"key": "dc.contributor.author", "value": "Lampinen, Essi", "language": null, "element": "contributor", "schema": "dc", "qualifier": "author"}, {"key": "dc.date.accessioned", "value": "2025-04-01T06:47:56Z", "language": null, "element": "date", "schema": "dc", "qualifier": "accessioned"}, {"key": "dc.date.available", "value": "2025-04-01T06:47:56Z", "language": null, "element": "date", "schema": "dc", "qualifier": "available"}, {"key": "dc.date.issued", "value": "2025", "language": null, "element": "date", "schema": "dc", "qualifier": "issued"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/101158", "language": null, "element": "identifier", "schema": "dc", "qualifier": "uri"}, {"key": "dc.description.abstract", "value": "Tutkielmassa k\u00e4sitell\u00e4\u00e4n syklodekstriinien ja niiden johdannaisten ominaisuuksia, jotka\nheikent\u00e4v\u00e4t virusten toimintaa vaikuttamalla solukolesteroliin tai sitoutumalla virusten\ntoiminalle tarpeellisiin proteiineihin. Syklodekstriinit ovat suuria sokerimolekyylej\u00e4, joilla on\nsyklinen kartiomainen rakenne. Syklodekstriinit pystyv\u00e4t sitomaan kolesterolia niiden\nrakenteelliseen hydrofobiseen onteloon solukalvon lipidirunsaasta alueesta, jota virukset\nhy\u00f6dynt\u00e4v\u00e4t hy\u00f6kk\u00e4yksess\u00e4 soluihin. T\u00e4m\u00e4n lis\u00e4ksi syklodekstriineilt\u00e4 on l\u00f6ydetty suora\nvaikutus virusten proteiineihin liittyen viruksen sitoutumiseen is\u00e4nt\u00e4soluun tai muuhun\nreplikaation vaiheeseen. Syklodekstriinej\u00e4 ja niiden johdannaisia hy\u00f6dynnet\u00e4\u00e4n jo laajasti\nl\u00e4\u00e4ketieteess\u00e4, mutta niiden suora vaikutus viruksiin on vasta tutkimusvaiheessa. Koska\nsyklodekstriinit on jo todettu ihmiskeholle turvallisiksi eik\u00e4 sytotoksisuutta ole havaittu\nvaikuttavilla pitoisuuksilla, syklodekstriinit tarjoavat erinomaisen mahdollisuuden laajan\nantiviraalinl\u00e4\u00e4kkeen kehitykselle.", "language": "fi", "element": "description", "schema": "dc", "qualifier": "abstract"}, {"key": "dc.description.abstract", "value": "", "language": "en", "element": "description", "schema": "dc", "qualifier": "abstract"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2025-04-01T06:47:56Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "schema": "dc", "qualifier": "provenance"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2025-04-01T06:47:56Z (GMT). No. of bitstreams: 0\n Previous issue date: 2025", "language": "en", "element": "description", "schema": "dc", "qualifier": "provenance"}, {"key": "dc.format.extent", "value": "24", "language": null, "element": "format", "schema": "dc", "qualifier": "extent"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "schema": "dc", "qualifier": "iso"}, {"key": "dc.rights", "value": "In Copyright", "language": null, "element": "rights", "schema": "dc", "qualifier": null}, {"key": "dc.subject.other", "value": "", "language": null, "element": "subject", "schema": "dc", "qualifier": "other"}, {"key": "dc.title", "value": "Syklodekstriinien antiviraaliset ominaisuudet", "language": null, "element": "title", "schema": "dc", "qualifier": null}, {"key": "dc.type", "value": "bachelor thesis", "language": null, "element": "type", "schema": "dc", "qualifier": null}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202504012985", "language": null, "element": "identifier", "schema": "dc", "qualifier": "urn"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "schema": "dc", "qualifier": "faculty"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "schema": "dc", "qualifier": "faculty"}, {"key": "dc.contributor.department", "value": "Kemian laitos", "language": "fi", "element": "contributor", "schema": "dc", "qualifier": "department"}, {"key": "dc.contributor.department", "value": "Department of Chemistry", "language": "en", "element": "contributor", "schema": "dc", "qualifier": "department"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": null, "element": "contributor", "schema": "dc", "qualifier": "organization"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": null, "element": "contributor", "schema": "dc", "qualifier": "organization"}, {"key": "dc.subject.discipline", "value": "Kemia", "language": "fi", "element": "subject", "schema": "dc", "qualifier": "discipline"}, {"key": "dc.subject.discipline", "value": "Chemistry", "language": "en", "element": "subject", "schema": "dc", "qualifier": "discipline"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_7a1f", "language": null, "element": "type", "schema": "dc", "qualifier": "coar"}, {"key": "dc.rights.copyright", "value": "\u00a9 The Author(s)", "language": "fi", "element": "rights", "schema": "dc", "qualifier": "copyright"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "schema": "dc", "qualifier": "accesslevel"}, {"key": "dc.type.publication", "value": "bachelorThesis", "language": null, "element": "type", "schema": "dc", "qualifier": "publication"}, {"key": "dc.subject.yso", "value": "virukset", "language": null, "element": "subject", "schema": "dc", "qualifier": "yso"}, {"key": "dc.subject.yso", "value": "virustaudit", "language": null, "element": "subject", "schema": "dc", "qualifier": "yso"}, {"key": "dc.subject.yso", "value": "syklodekstriinit", "language": null, "element": "subject", "schema": "dc", "qualifier": "yso"}, {"key": "dc.subject.yso", "value": "l\u00e4\u00e4keaineet", "language": null, "element": "subject", "schema": "dc", "qualifier": "yso"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "schema": "dc", "qualifier": "url"}, {"key": "dc.description.accessibilityfeature", "value": "unknown accessibility", "language": "en", "element": "description", "schema": "dc", "qualifier": "accessibilityfeature"}, {"key": "dc.description.accessibilityfeature", "value": "ei tietoa saavutettavuudesta", "language": "fi", "element": "description", "schema": "dc", "qualifier": "accessibilityfeature"}]
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