CFTR TCPTP VAP-1 filamiinit filamin hydratsiini hydrazine ligand binding pockets ligandinsitomistaskut molecular dynamics molekyylidynamiikka rationaalinen lääkeainesuunnittelu rational drug discovery vascular adhesion protein 1 vaskulaarinen adheesioproteiini 1 Cell Adhesion Molecules Chemistry, Pharmaceutical Drug Discovery Filamins Hydrazines Ligands Molecular Dynamics Simulation Molecular Structure PDB ID 2JF1 Protein Tyrosine Phosphatases Proteins Vascular Cell Adhesion Molecule-1 dynamiikka filamiini A integriini